Comparative Pharmacokinetics of Bupivacaine and Ropivacaine,... : Anesthesia &
Analgesia Comparative Pharmacokinetics of Bupivacaine and Ropivacaine, a New Amide …

Background Ropivacaine is a new amide local anesthetic, having therapeutic properties
similar to those of bupivacaine but with a wider margin of safety. Bupivacaine is probably the …

The protonation equilibrium and hydrophobic character of lidocaine were characterized by
its pKa and the octanol: buffer partition coefficients of the charged (P+) and neutral (P0) drug …

Injection of lidocaine into the subcutaneous tissues by the tumescent technique results in a
delayed absorption of the local anesthetic and has allowed clinicians to exceed the …

Ropivacaine is a new local anesthetic that is chemically related to mepivacaine and
bupivacaine. Previous laboratory studies have demonstrated that ropivacaine possesses an …

Abstract Convulsant doses of lidocaine (11.0-16.5 mg/kg) and bupivacaine (3.4-5.1 mg/kg)
were administered intravenously at 48-hour intervals in a randomized crossover design to …

Local anesthetic solutions of varying density and patient position are used to control the
dermatomal spread of anesthesia after the intrathecal injection of local anesthetics. Density …

The effect of sodium thiopental (6 and 20 μ g/ml) on the protein binding of bupivacaine in
human serum was determined at pH values of 7.40 and 7.00. The protein binding of …

Methods Forty-nine patients, aged 55 or older, undergoing elective total hip arthroplasty,
had arterial plasma bupivacaine concentrations measured (gas chromatography) at 10 …

Total spinal anesthesia was induced in dogs by the intrathecal injection of 10 ml of 0.5%
bupivacaine with and without epinephrine. A decrease of approximately 40% to 50% in …