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Locally Injected Dexmedetomidine Induces Vasoconstriction via Peripheral α-2A Adrenoceptor Subtype in Guinea Pigs
  1. Akiko Yabuki, DDS*,
  2. Hitoshi Higuchi, DDS, PhD†,
  3. Tatsushi Yoshitomi, DDS, PhD‡,
  4. Yumiko Tomoyasu, DDS, PhD*,
  5. Minako Ishii-Maruhama, DDS, PhD†,
  6. Shigeru Maeda, DDS, PhD† and
  7. Takuya Miyawaki, DDS, PhD*
  1. *Department of Dental Anesthesiology and Special Care Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
  2. †Department of Dental Anesthesiology, Okayama University Hospital, Okayama, Japan
  3. ‡Dental Clinic, Okayama Kyoritsu General Hospital, Okayama, Japan
  1. Address correspondence to: Takuya Miyawaki, DDS, PhD, Department of Dental Anesthesiology and Special Care Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8525, Japan (e-mail: miyawaki{at}md.okayama-u.ac.jp).

Abstract

Background and Objectives Recent research shows that locally injected dexmedetomidine enhances the local anesthetic potency of lidocaine via the α-2A adrenoceptor subtype in guinea pigs. However, little is known about the effect of locally injected dexmedetomidine on the peripheral vascular response. This study aimed to evaluate the effect of locally injected dexmedetomidine on the peripheral vascular response, measuring skin blood flow in the injected area in guinea pigs.

Methods Dexmedetomidine was intracutaneously injected at a volume of 0.1 mL into the backs of guinea pigs, and further injected combined with yohimbine, a selective antagonist of α-2 adrenoceptors, or prazosin, a selective antagonist of α-1 adrenoceptors and an antagonist of both α-2B and α-2C adrenoceptor subtypes. Skin blood flow was measured until 60 minutes after injection using a laser-Doppler flowmeter. Furthermore, systemic arterial blood pressure and pulse of the guinea pigs were monitored via a catheter inserted into the carotid artery throughout every experiment.

Results Dexmedetomidine at a concentration of 1 μM significantly decreased the skin blood flow in a dose-dependent manner with no changes in the mean blood pressure and pulse. Yohimbine completely antagonized the effect of dexmedetomidine, but prazosin did not.

Conclusions The results reveal that locally injected dexmedetomidine at a concentration of 1 μM induced peripheral vasoconstriction without a systemic cardiovascular response via the peripheral α-2A adrenoceptor subtype.

https://doi.org/10.1097/AAP.0000000000000048

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    Footnotes

    • The authors declare no conflict of interest.

      Financial support was provided by Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

      This work is attributed to Department of Dental Anesthesiology and Special Care Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.