The brain microvascular network is comprised of capillaries, arterioles and venules, all of
which retain – although to a different extent – blood-brain barrier (BBB) properties. Capillaries …

The blood-brain barrier (BBB) is an active interface between the circulation and the central
nervous system (CNS) with a dual function: the barrier function restricts the transport from the …

Previous studies have shown that modulation of the receptor-mediated cannabinoid system
during neuroinflammation can produce potent neuroprotective and anti-inflammatory effects. …

A cell's “redox” (oxidation and reduction) state is determined by the sum of all redox processes
yielding reactive oxygen species (ROS), reactive nitrogen species (RNS), and other …

The structure and function of the barrier layers restricting the free diffusion of substances
between the central nervous system (brain and spinal cord) and the systemic circulation is of …

Zonula occludens proteins (ZOPs), currently comprising ZO-1, ZO-2, and ZO-3, belong to
the family of membrane-associated guanylate kinase homologue (MAGUK) proteins that are …

Cerebral endothelial cells – the principal components of the blood–brain barrier (BBB) –
fulfill several important functions in the central nervous system (CNS). They form an active …

The majority of brain metastases originate from lung cancer, breast cancer and malignant
melanoma. In order to reach the brain, parenchyma metastatic cells have to transmigrate …

The most important obstacle to the drug delivery into the brain is the presence of the blood–brain
barrier, which limits the traffic of substances between the blood and the nervous tissue. …

Tight junctions create a highly selective diffusion barrier between epithelial and endothelial
cells by preventing the free passage of molecules and ions across the paracellular pathway. …