Propofol is an intravenous agent used commonly for the induction and maintenance of
anesthesia, procedural, and critical care sedation in children. The mechanisms of action on …

Inadequate pain relief and adverse effects from analgesics remain common in children and
adults during the perioperative period. Opioids are the most commonly used analgesics in …

Although routine preoperative genotyping to identify children at risk and personalized opioid
use for pediatric perioperative pain management is still a distant reality, current known …

BACKGROUND: Interindividual variability in pain perception and analgesic response is a
major problem in perioperative practice. Adult studies suggest pain management is …

Aim: Large interindividual variability in morphine disposition could contribute to
unpredictable variability in morphine analgesia and adverse events. Caucasian children …

Background: Effective perioperative analgesia is lacking for children owing to interindividual
variations and underdosing of opioids caused by fear of adverse effects. We investigated the …

Aim: Large interindividual variability in morphine pharmacokinetics could contribute to
variability in morphine analgesia and adverse events. Methods: Influence of weight, genetic …

This article reviews and summarizes current evidence and knowledge gaps regarding
postoperative analgesia after pediatric posterior spine fusion for adolescent idiopathic …

Introduction The perioperative pain experience shows great interindividual variability and is
difficult to predict. The mu-1 opioid receptor gene (OPRM1) is known to play an important …

Aim: Oxycodone is partly metabolized to the active metabolite oxymorphone by hepatic
CYP2D6 in the liver. Significant genetic variability in CYP2D6 activity affects oxymorphone …