Definition of the hypothalamic GnRH pulse generator in mice

…, SY Han, R Piet, T McLennan… - Proceedings of the …, 2017 - National Acad Sciences
The pulsatile release of luteinizing hormone (LH) is critical for mammalian fertility. However,
despite several decades of investigation, the identity of the neuronal network generating …

Smooth surface reconstruction from noisy range data

JC Carr, RK Beatson, BC McCallum, WR Fright… - Proceedings of the 1st …, 2003 - dl.acm.org
This paper shows that scattered range data can be smoothed at low cost by fitting a Radial
Basis Function (RBF) to the data and convolving with a smoothing kernel (low pass filtering) …

Selective optogenetic activation of arcuate kisspeptin neurons generates pulsatile luteinizing hormone secretion

SY Han, T McLennan, K Czieselsky… - Proceedings of the …, 2015 - National Acad Sciences
Normal reproductive functioning in mammals depends upon gonadotropin-releasing
hormone (GnRH) neurons generating a pulsatile pattern of gonadotropin secretion. The …

[PDF][PDF] Rapid geological modelling

EJ Cowan, RK Beatson, WR Fright… - … structural geology for …, 2002 - researchgate.net
Leapfrog™ software allows the construction of three-dimensional (3D) geological models
from raw drillhole data in a matter of minutes to hours, as opposed to days of manual …

MBD4 guards against methylation damage and germ line deficiency predisposes to clonal hematopoiesis and early-onset AML

…, B Luiken, M Rijken, T Mclennan… - Blood, The Journal …, 2018 - ashpublications.org
Abstract The tendency of 5-methylcytosine (5mC) to undergo spontaneous deamination has
had a major role in shaping the human genome, and this methylation damage remains the …

[PDF][PDF] MOZ regulates the Tbx1 locus, and Moz mutation partially phenocopies DiGeorge syndrome

AK Voss, HK Vanyai, C Collin, MP Dixon… - Developmental cell, 2012 - cell.com
DiGeorge syndrome, caused by a 22q11 microdeletion or mutation of the TBX1 gene, varies
in severity greatly, even among monozygotic twins. Epigenetic phenomena have been …

Dominant neuropeptide cotransmission in kisspeptin-GABA regulation of GnRH neuron firing driving ovulation

R Piet, B Kalil, T McLennan, R Porteous… - Journal of …, 2018 - Soc Neuroscience
A population of kisspeptin-GABA coexpressing neurons located in the rostral periventricular
area of the third ventricle (RP3V) is believed to activate gonadotropin-releasing hormone …

Defining subpopulations of arcuate nucleus GABA neurons in male, female, and prenatally androgenized female mice

CJ Marshall, E Desroziers, T McLennan… - …, 2017 - karger.com
Abstract Background/Aims: Arcuate nucleus (ARN) γ-aminobutyric acid (GABA) neurons are
implicated in many critical homeostatic mechanisms, from food intake to fertility. To …

Review of literature on interventions aimed at resolving problems caused by predatory behaviour in dogs (Canis familiaris)

T McLennan - Applied Animal Behaviour Science, 2023 - Elsevier
Predatory behaviour is undesirable in pet dogs (Canis familiaris) due to the risks it poses to
livestock, protected wildlife, and other pets. Some researchers believe that it also poses risks …

[BOOK][B] Africa's Automotive Industry: Potential and Challenges

AH Black, B Makundi, T McLennan - 2017 - academia.edu
The low level of industrialisation is a major problem in Africa. Many analysts have argued
that lack of structural change during the phase of economic expansion since 2000 will …