Abstract Background The NaV1. 8 voltage-gated sodium channel, expressed in peripheral
nociceptive neurons, plays a role in transmitting nociceptive signals. The effect of VX-548 …

Background and objectives Obtaining consistent efficacy beyond 12–24 hours with local
anesthetics, including extended-release formulations, has been a challenging goal …

Background HTX-011 is an extended-release, dual-acting local anesthetic consisting of
bupivacaine and low-dose meloxicam in a novel polymer that is administered by needle-free …

Objective To evaluate the ability of efinaconazole vehicle to reach the site of toenail
onychomycosis by spreading through the subungual space between the nail plate and nail …

Objective To assess the potential efficacy, safety, and optimal dosing concentration of
tavaborole, a novel, boron-based pharmaceutical agent with broad-spectrum antifungal …

Objective: To evaluate the analgesic efficacy and safety of a novel intravenous (IV)
formulation of meloxicam (30 mg) in patients with moderate-to-severe pain following a …

Complications of lesser metatarsal surgery are the result of inappropriate procedure choice,
poor surgical technique, inadequate fixation, or a lack of patient compliance. Postoperative …

Background Toenail onychomycosis is a common disease with limited treatment options;
treatment failure and relapse are frequently encountered. Many patients experience long …

To provide an adequate therapeutic effect against onychomycosis, it has been suggested
that topical drugs should have two properties: drug permeability through the nail plate and …

We appreciate the comments provided by Hafer and Johnson 1 regarding our recent
manuscript. 2 Their primary concern appears to be the clinical evidence supporting the …