Pain medication plays an important role in the treatment of acute and chronic pain
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …

Use of opioid analgesics for pain management has increased dramatically over the past
decade, with corresponding increases in negative sequelae including overdose and death …

Functional imaging studies of human subjects have identified a diverse assortment of brain
areas that are engaged in the processing of pain. Although many of these brain areas are …

Detecting autoantibodies provides foundational information for the diagnosis of most
autoimmune diseases. An important pathophysiological distinction is whether …

Following chronic cocaine treatment, we have found a long-lasting increase in AP-1 binding
in the rat nucleus accumbens and striatum, two important targets of the behavioral effects of …

The protooncogene c-fos produces a phosphoprotein, Fos, which regulates gene
transcription processes. In neuronal systems, Fos has been proposed to couple synaptic …

Localization of the anatomic substrate for anticonvulsant activity mediated by γ-aminobutyric
acid (GABA) was examined using intracerebral injections of GABA agonists. Blockade of …

While a variety of cultural, psychological and physiological factors contribute to variability in
both clinical and experimental contexts, the role of genetic factors in human pain sensitivity …

Control of cancer, neuropathic, and postoperative pain is frequently inadequate or
compromised by debilitating side effects. Inhibition or removal of certain nociceptive …

Abstract The PET H2 15O-bolus method was used to image regional brain activity in normal
human subjects during intense pain induced by intradermal injection of capsaicin and …