Small animal imaging with magnetic resonance microscopy

B Driehuys, J Nouls, A Badea, E Bucholz… - ILAR …, 2008 - academic.oup.com
Small animal magnetic resonance microscopy (MRM) has evolved significantly from testing
the boundaries of imaging physics to its expanding use today as a tool in noninvasive …

Mechanism of detection of acute cerebral ischemia in rats by diffusion-weighted magnetic resonance microscopy.

H Benveniste, LW Hedlund, GA Johnson - Stroke, 1992 - Am Heart Assoc
The aim of this study was to measure apparent diffusion coefficients in rat brain tissue
exposed to ouabain, glutamate, and N-methyl-D-aspartate and to compare them with …

Imaging alveolar–capillary gas transfer using hyperpolarized 129Xe MRI

B Driehuys, GP Cofer, J Pollaro… - Proceedings of the …, 2006 - National Acad Sciences
Effective pulmonary gas exchange relies on the free diffusion of gases across the thin tissue
barrier separating airspace from the capillary red blood cells (RBCs). Pulmonary …

A liposomal nanoscale contrast agent for preclinical CT in mice

S Mukundan Jr, KB Ghaghada… - American Journal of …, 2006 - Am Roentgen Ray Soc
OBJECTIVE. The goal of this study was to determine if an iodinated, liposomal contrast
agent could be used for high-resolution, micro-CT of low-contrast, small-size vessels in a …

Morphologic phenotyping with MR microscopy: the visible mouse

GA Johnson, GP Cofer, SL Gewalt, LW Hedlund - Radiology, 2002 - pubs.rsna.org
A method for rapid morphologic phenotyping is demonstrated by using magnetic resonance
microscopy. Whole fixed C57BL/6J mice were imaged at 110-μm isotropic resolution; limited …

Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: diffusion coefficient

XJ Chen, HE Möller, MS Chawla… - … in Medicine: An …, 1999 - Wiley Online Library
In imaging of hyperpolarized noble gases, a knowledge of the diffusion coefficient (D) is
important both as a contrast mechanism and in the design of pulse sequences. We have …

Intertumoral differences in hypoxia selectivity of the PET imaging agent 64Cu (II)-diacetyl-bis (N4-methylthiosemicarbazone)

H Yuan, T Schroeder, JE Bowsher… - Journal of Nuclear …, 2006 - Soc Nuclear Med
Cu-Diacetyl-bis (N 4-methylthiosemicarbazone)(Cu-ATSM) is a recently developed PET
imaging agent for tumor hypoxia. However, its accuracy and reliability for measuring hypoxia …

Utilizing MRI information to estimate F18-FDG distributions in rat flank tumors

JE Bowsher, H Yuan, LW Hedlund… - IEEE Symposium …, 2004 - ieeexplore.ieee.org
This paper investigates the potential of magnetic resonance imaging (MRI) to improve the
estimation of within-tumor variations in F18-FDG concentration. An image model is …

4-D micro-CT of the mouse heart

CT Badea, B Fubara, LW Hedlund… - Molecular …, 2005 - journals.sagepub.com
Purpose: Demonstrate noninvasive imaging methods for in vivo characterization of cardiac
structure and function in mice using a micro-CT system that provides high photon fluence …

Detection of emphysema in rat lungs by using magnetic resonance measurements of 3He diffusion

XJ Chen, LW Hedlund, HE Möller… - Proceedings of the …, 2000 - National Acad Sciences
Emphysema is a pulmonary disease characterized by alveolar wall destruction, resulting in
enlargement of gas exchange spaces without fibrosis. This condition is a part of chronic …