Highlights•Drug assays in oncology need new preclinical models to better mimic human
tumors.•Organoids are 3D ex vivo models that can be derived from human …

Objectives We studied the relation between the polymorphism of P-glycoprotein (P-gp) and
of breast cancer resistance protein (BCRP), encoded by ABCB1 and ABCG2 genes …

A survey study, using a questionnaire, was conducted in 161 students and workers in a
French engineering school on symptoms experienced during use of digital cellular phones …

Controversial results have been published in the literature concerning the efficacy of
alkalinization of solutions of local anesthetics to shorten the time to onset of sensory block …

The authors examined immunological disorders in 6 individuals who had been exposed
occupationally to environmental electromagnetic fields. Comparable effects on mice …

Background. Cyclosporine A (CsA) is characterized by high interindividual variations in oral
bioavailability and a narrow therapeutic index. CsA is a substrate for P-glycoprotein, a …

Prolonged cannabis use has a significant impact on health and well-being. Genetic factors
are known to influence cannabis dependence, but few specific genetic markers have been …

Study objective: Increasing the pH of an epinephrine solution favors its oxidation and may
result in a decrease in its biological activity. It is therefore generally assumed that …

ABSTRACT P‐glycoprotein (P‐gp) plays a major role in drug efflux. All the transported
substrates are more or less hydrophobic and amphiphatic in nature. Being lipophilic, Δ9 …

Objective To characterise the interactions between tacrolimus and antiretroviral drug
combinations in hepatitis C virus-HIV co-infected patients who had received a liver …