User profiles for "author:Karen Lam"

Karen Lam

Chair Professor in Medicine, the University of Hong Kong
Verified email at hku.hk
Cited by 47517

Contribution of polyol pathway to diabetes-induced oxidative stress

SSM Chung, ECM Ho, KSL Lam… - Journal of the American …, 2003 - journals.lww.com
Diabetes causes increased oxidative stress, which is thought to play an important role in the
pathogenesis of various diabetic complications. However, the source of the hyperglycemia …

The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic

L Geng, KSL Lam, A Xu - Nature Reviews Endocrinology, 2020 - nature.com
Abstract Fibroblast growth factor 21 (FGF21) is a stress-inducible hormone that has
important roles in regulating energy balance and glucose and lipid homeostasis through a …

Post-translational modifications of adiponectin: mechanisms and functional implications

Y Wang, KSL Lam, M Yau, A Xu - Biochemical Journal, 2008 - portlandpress.com
Adiponectin is an insulin-sensitizing adipokine with anti-diabetic, anti-atherogenic, anti-
inflammatory and cardioprotective properties. This adipokine is secreted from adipocytes …

Obstructive sleep apnea is independently associated with insulin resistance

MSM Ip, B Lam, MMT Ng, WK Lam… - American journal of …, 2002 - atsjournals.org
Epidemiological studies have implicated obstructive sleep apnea (OSA) as an independent
comorbid factor in cardiovascular and cerebrovascular diseases. It is postulated that …

Prevalence, awareness, treatment, and control of hypertension among United States adults 1999–2004

KL Ong, BMY Cheung, YB Man, CP Lau, KSL Lam - Hypertension, 2007 - Am Heart Assoc
Detection of hypertension and blood pressure control are critically important for reducing the
risk of heart attacks and strokes. We analyzed the trends in the prevalence, awareness …

[HTML][HTML] The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice

A Xu, Y Wang, H Keshaw, LY Xu… - The Journal of …, 2003 - Am Soc Clin Investig
Adiponectin has recently been shown to be a promising candidate for the treatment of
obesity-associated metabolic syndromes. Replenishment of recombinant adiponectin in …

Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans

X Zhang, DCY Yeung, M Karpisek, D Stejskal… - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—Fibroblast growth factor 21 (FGF21) is a metabolic regulator with multiple
beneficial effects on glucose homeostasis and insulin sensitivity in animal models. This …

Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans

Y Wang, KSL Lam, EW Kraegen, G Sweeney… - Clinical …, 2007 - academic.oup.com
Abstract Background: Lipocalin-2, a 25-kDa secreted glycoprotein, is a useful biomarker for
early detection of various renal injuries. Because lipocalin-2 is abundantly expressed in …

Adipocyte fatty acid–binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome

A Xu, YU Wang, JY Xu, D Stejskal, S Tam… - Clinical …, 2006 - academic.oup.com
Background: Adipocyte fatty acid–binding protein (A-FABP) is traditionally thought to be a
cytosolic fatty acid chaperone expressed in adipocytes. Mice with targeted disruption of the …

Serum leptin and vascular risk factors in obstructive sleep apnea

MSM Ip, KSL Lam, C Ho, KWT Tsang, W Lam - Chest, 2000 - Elsevier
Study objectives To define the metabolic profilerelevant to vascular risks in obstructive sleep
apnea (OSA) and therole of leptin resistance in this risk profile. Design Case control study …