User profiles for "author:Karen Lam"
Karen LamChair Professor in Medicine, the University of Hong Kong Verified email at hku.hk Cited by 47517 |
Contribution of polyol pathway to diabetes-induced oxidative stress
SSM Chung, ECM Ho, KSL Lam… - Journal of the American …, 2003 - journals.lww.com
Diabetes causes increased oxidative stress, which is thought to play an important role in the
pathogenesis of various diabetic complications. However, the source of the hyperglycemia …
pathogenesis of various diabetic complications. However, the source of the hyperglycemia …
The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic
Abstract Fibroblast growth factor 21 (FGF21) is a stress-inducible hormone that has
important roles in regulating energy balance and glucose and lipid homeostasis through a …
important roles in regulating energy balance and glucose and lipid homeostasis through a …
Post-translational modifications of adiponectin: mechanisms and functional implications
Adiponectin is an insulin-sensitizing adipokine with anti-diabetic, anti-atherogenic, anti-
inflammatory and cardioprotective properties. This adipokine is secreted from adipocytes …
inflammatory and cardioprotective properties. This adipokine is secreted from adipocytes …
Obstructive sleep apnea is independently associated with insulin resistance
MSM Ip, B Lam, MMT Ng, WK Lam… - American journal of …, 2002 - atsjournals.org
Epidemiological studies have implicated obstructive sleep apnea (OSA) as an independent
comorbid factor in cardiovascular and cerebrovascular diseases. It is postulated that …
comorbid factor in cardiovascular and cerebrovascular diseases. It is postulated that …
Prevalence, awareness, treatment, and control of hypertension among United States adults 1999–2004
Detection of hypertension and blood pressure control are critically important for reducing the
risk of heart attacks and strokes. We analyzed the trends in the prevalence, awareness …
risk of heart attacks and strokes. We analyzed the trends in the prevalence, awareness …
[HTML][HTML] The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
Adiponectin has recently been shown to be a promising candidate for the treatment of
obesity-associated metabolic syndromes. Replenishment of recombinant adiponectin in …
obesity-associated metabolic syndromes. Replenishment of recombinant adiponectin in …
Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans
X Zhang, DCY Yeung, M Karpisek, D Stejskal… - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—Fibroblast growth factor 21 (FGF21) is a metabolic regulator with multiple
beneficial effects on glucose homeostasis and insulin sensitivity in animal models. This …
beneficial effects on glucose homeostasis and insulin sensitivity in animal models. This …
Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans
Abstract Background: Lipocalin-2, a 25-kDa secreted glycoprotein, is a useful biomarker for
early detection of various renal injuries. Because lipocalin-2 is abundantly expressed in …
early detection of various renal injuries. Because lipocalin-2 is abundantly expressed in …
Adipocyte fatty acid–binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome
Background: Adipocyte fatty acid–binding protein (A-FABP) is traditionally thought to be a
cytosolic fatty acid chaperone expressed in adipocytes. Mice with targeted disruption of the …
cytosolic fatty acid chaperone expressed in adipocytes. Mice with targeted disruption of the …
Serum leptin and vascular risk factors in obstructive sleep apnea
MSM Ip, KSL Lam, C Ho, KWT Tsang, W Lam - Chest, 2000 - Elsevier
Study objectives To define the metabolic profilerelevant to vascular risks in obstructive sleep
apnea (OSA) and therole of leptin resistance in this risk profile. Design Case control study …
apnea (OSA) and therole of leptin resistance in this risk profile. Design Case control study …