Neurotoxicity of adjuvants used in perineural anesthesia and analgesia in comparison with ropivacaine

BA Williams, KA Hough, BYK Tsui… - Regional Anesthesia & …, 2011 - rapm.bmj.com
Background and Objectives: Clonidine, buprenorphine, dexamethasone, and midazolam (C,
B, D, M) have been used to prolong perineural local anesthesia in the absence of data on …

Effect of adjuvant drugs on the action of local anesthetics in isolated rat sciatic nerves

E Yilmaz-Rastoder, MS Gold, KA Hough… - Regional Anesthesia & …, 2012 - rapm.bmj.com
Background and Objectives There is increasing clinical use of adjuvant drugs to prolong the
duration of local anesthetic–induced block of peripheral nerves. However, the mechanistic …

Mechanisms underlying midazolam-induced peripheral nerve block and neurotoxicity

E Yilmaz, KA Hough, GF Gebhart… - Regional Anesthesia & …, 2014 - rapm.bmj.com
Background and Objectives The benzodiazepine midazolam has been reported to facilitate
the actions of spinally administrated local anesthetics. Interestingly, despite the lack of …