Neurodegenerative lysosomal disorders: a continuum from development to late age
Neuronal survival requires continuous lysosomal turnover of cellular constituents delivered
by autophagy and endocytosis. Primary lysosomal dysfunction in inherited congenital …
by autophagy and endocytosis. Primary lysosomal dysfunction in inherited congenital …
[HTML][HTML] Material aspects of triboelectric energy generation and sensors
The triboelectric nanogenerator (TENG) is a new type of energy generator first demonstrated
in 2012. TENGs have shown potential as power sources for electronic devices and as …
in 2012. TENGs have shown potential as power sources for electronic devices and as …
Recent advances in self‐powered tribo‐/piezoelectric energy harvesters: all‐in‐one package for future smart technologies
Electric devices has become a necessity in modern smart societies. The energy research
community is continually exploring new solutions that can be employed as potential and …
community is continually exploring new solutions that can be employed as potential and …
[HTML][HTML] Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques
Autophagy is markedly impaired in Alzheimer's disease (AD). Here we reveal unique
autophagy dysregulation within neurons in five AD mouse models in vivo and identify its …
autophagy dysregulation within neurons in five AD mouse models in vivo and identify its …
[HTML][HTML] Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations
Macroautophagy is a lysosomal degradative pathway essential for neuron survival. Here, we
show that macroautophagy requires the Alzheimer's disease (AD)-related protein presenilin …
show that macroautophagy requires the Alzheimer's disease (AD)-related protein presenilin …
Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease
Macroautophagy, which is a lysosomal pathway for the turnover of organelles and long-lived
proteins, is a key determinant of cell survival and longevity. In this study, we show that …
proteins, is a key determinant of cell survival and longevity. In this study, we show that …
Copper (II)-induced self-oligomerization of α-synuclein
α-Synuclein is a component of the abnormal protein depositions in senile plaques and Lewy
bodies of Alzheimer's disease (AD) and Parkinson's disease respectively. The protein was …
bodies of Alzheimer's disease (AD) and Parkinson's disease respectively. The protein was …
Autophagy failure in A lzheimer's disease and the role of defective lysosomal acidification
Autophagy is a lysosomal degradative process which recycles cellular waste and eliminates
potentially toxic damaged organelles and protein aggregates. The important cytoprotective …
potentially toxic damaged organelles and protein aggregates. The important cytoprotective …
Hepatocellular carcinoma treated with percutaneous radio-frequency ablation: evaluation with follow-up multiphase helical CT
HK Lim, D Choi, WJ Lee, SH Kim, SJ Lee, HJ Jang… - Radiology, 2001 - pubs.rsna.org
PURPOSE: To determine serial changes in hepatocellular carcinomas (HCCs) treated with
percutaneous radio-frequency (RF) ablation at long-term follow-up multiphase helical …
percutaneous radio-frequency (RF) ablation at long-term follow-up multiphase helical …
[PDF][PDF] Presenilin 1 maintains lysosomal Ca2+ homeostasis via TRPML1 by regulating vATPase-mediated lysosome acidification
JH Lee, MK McBrayer, DM Wolfe, LJ Haslett, A Kumar… - Cell reports, 2015 - cell.com
Summary Presenilin 1 (PS1) deletion or Alzheimer's disease (AD)-linked mutations disrupt
lysosomal acidification and proteolysis, which inhibits autophagy. Here, we establish that …
lysosomal acidification and proteolysis, which inhibits autophagy. Here, we establish that …