User profiles for "author:Ju Hyun Lee"

JU-HYUN LEE

- Verified email at NKI.RFMH.ORG - Cited by 18450

Ju-Hyun Lee

- Verified email at korea.ac.kr - Cited by 525

Neurodegenerative lysosomal disorders: a continuum from development to late age

RA Nixon, DS Yang, JH Lee - Autophagy, 2008 - Taylor & Francis
Neuronal survival requires continuous lysosomal turnover of cellular constituents delivered
by autophagy and endocytosis. Primary lysosomal dysfunction in inherited congenital …

[HTML][HTML] Material aspects of triboelectric energy generation and sensors

DW Kim, JH Lee, JK Kim, U Jeong - NPG Asia Materials, 2020 - nature.com
The triboelectric nanogenerator (TENG) is a new type of energy generator first demonstrated
in 2012. TENGs have shown potential as power sources for electronic devices and as …

Recent advances in self‐powered tribo‐/piezoelectric energy harvesters: all‐in‐one package for future smart technologies

SK Karan, S Maiti, JH Lee, YK Mishra… - Advanced Functional …, 2020 - Wiley Online Library
Electric devices has become a necessity in modern smart societies. The energy research
community is continually exploring new solutions that can be employed as potential and …

[HTML][HTML] Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques

JH Lee, DS Yang, CN Goulbourne, E Im… - Nature …, 2022 - nature.com
Autophagy is markedly impaired in Alzheimer's disease (AD). Here we reveal unique
autophagy dysregulation within neurons in five AD mouse models in vivo and identify its …

[HTML][HTML] Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

JH Lee, WH Yu, A Kumar, S Lee, PS Mohan… - Cell, 2010 - cell.com
Macroautophagy is a lysosomal degradative pathway essential for neuron survival. Here, we
show that macroautophagy requires the Alzheimer's disease (AD)-related protein presenilin …

Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease

WH Yu, AM Cuervo, A Kumar, CM Peterhoff… - The Journal of cell …, 2005 - rupress.org
Macroautophagy, which is a lysosomal pathway for the turnover of organelles and long-lived
proteins, is a key determinant of cell survival and longevity. In this study, we show that …

Copper (II)-induced self-oligomerization of α-synuclein

SR Paik, HJ SHIN, JH LEE, CS CHANG… - Biochemical …, 1999 - portlandpress.com
α-Synuclein is a component of the abnormal protein depositions in senile plaques and Lewy
bodies of Alzheimer's disease (AD) and Parkinson's disease respectively. The protein was …

Autophagy failure in A lzheimer's disease and the role of defective lysosomal acidification

DM Wolfe, J Lee, A Kumar, S Lee… - European journal of …, 2013 - Wiley Online Library
Autophagy is a lysosomal degradative process which recycles cellular waste and eliminates
potentially toxic damaged organelles and protein aggregates. The important cytoprotective …

Hepatocellular carcinoma treated with percutaneous radio-frequency ablation: evaluation with follow-up multiphase helical CT

HK Lim, D Choi, WJ Lee, SH Kim, SJ Lee, HJ Jang… - Radiology, 2001 - pubs.rsna.org
PURPOSE: To determine serial changes in hepatocellular carcinomas (HCCs) treated with
percutaneous radio-frequency (RF) ablation at long-term follow-up multiphase helical …

[PDF][PDF] Presenilin 1 maintains lysosomal Ca2+ homeostasis via TRPML1 by regulating vATPase-mediated lysosome acidification

JH Lee, MK McBrayer, DM Wolfe, LJ Haslett, A Kumar… - Cell reports, 2015 - cell.com
Summary Presenilin 1 (PS1) deletion or Alzheimer's disease (AD)-linked mutations disrupt
lysosomal acidification and proteolysis, which inhibits autophagy. Here, we establish that …