The pharmacokinetic properties of a drug comprise the relationship between its absorption,
distribution and inactivation. The passage of drugs across cell membranes is a key part of …

Background: Based on equivocal clinical data, intravenous antioxidant therapy has been
used for the treatment of severe acute pancreatitis. To date there is no randomised …

The classification of drug interactions is first considered in this article, with an explanation of
the terminology. Emphasis is placed on the importance of the topic in relation to the …

IMPLICATIONS: Using an original, validated, high-fidelity model of pulmonary physiology,
we have demonstrated that the arterial to end-tidal carbon dioxide pressure gradient may be …

Background There is on-going controversy regarding the potential for increased respiratory
effort to generate patient self-inflicted lung injury (P-SILI) in spontaneously breathing …

Background Postoperative ulnar neuropathy (PUN) is an injury manifesting in the sensory or
motor distribution of the ulnar nerve after anaesthesia or surgery. The condition frequently …

BACKGROUND: Although mesenteric angiography and embolization are established
radiologic procedures, the evidence-base to aid decision making regarding selection of …

Background Recent analyses of patient data in acute respiratory distress syndrome (ARDS)
showed that a lower ventilator driving pressure was associated with reduced relative risk of …

Objective: To develop a compact probe that can be used to monitor humidity in ventilator
care equipment. A mesoporous film of alternate layers of Poly (allylamine …

Objectives: Mechanical power and driving pressure have been proposed as indicators, and
possibly drivers, of ventilator-induced lung injury. We tested the utility of these different …