Thalidomide was a widely used drug in the late 1950s and early 1960s for the treatment of
nausea in pregnant women. It became apparent in the 1960s that thalidomide treatment …

Abstract In Victoria, Australia, both dryland salinity and salinity in irrigation regions are
serious agricultural problems. One option to control the latter is to pump groundwater to …

Scholars hold different perspectives about leadership which are not limited to a formally
appointed leader. Of the abundance of terms used to describe this phenomenon, shared …

Background: Up-regulation of γ-aminobutyric acid A (GABA A) receptors and decreased
GABA uptake in the cerebral cortex of schizophrenics suggest altered GABAergic …

Excessive and prolonged activity of inflammatory monocytes is a hallmark of many diseases
with an inflammatory component. In such conditions, precise targeting of these cells could …

A general approach for heritably altering gene expression has the potential to enable many
discovery and therapeutic efforts. Here, we present CRISPRoff—a programmable epigenetic …

Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era.
We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data …

In a screen of drugs previously tested in humans we identified itraconazole, a systemic
antifungal, as a potent antagonist of the Hedgehog (Hh) signaling pathway that acts by a …

An RNA model system consisting of an oligomer binding to a 4-nt overhang at the 5'end of a
hairpin stem provides thermodynamic parameters for helix-helix interfaces. In a sequence …

The accountability requirements of the No Child Left Behind Act of 2001 place high-poverty
schools and racially diverse schools at a disadvantage because they rely on mean …