Although recent genome-wide studies have provided valuable insights into the genetic basis
of human disease, they have explained relatively little of the heritability of most complex …

Genome-wide association studies (GWAS) have evolved over the last ten years into a
powerful tool for investigating the genetic architecture of human disease. In this work, we …

Feature selection plays a critical role in biomedical data mining, driven by increasing feature
dimensionality in target problems and growing interest in advanced but computationally …

One of the greatest challenges facing human geneticists is the identification and
characterization of susceptibility genes for common complex multifactorial human diseases …

Africa is the source of all modern humans, but characterization of genetic variation and of
relationships among populations across the continent has been enigmatic. We studied 121 …

Motivation: Polymorphisms in human genes are being described in remarkable numbers.
Determining which polymorphisms and which environmental factors are associated with …

There is increasing awareness that epistasis or gene-gene interaction plays a role in
susceptibility to common human diseases. In this paper, we formulate a working hypothesis …

MicroRNAs are small noncoding RNAs that function by regulating target gene expression
posttranscriptionally. They play a critical role in developmental and physiologic processes …

Background Proteomics-based approaches complement the genome initiatives and may be
the next step in attempts to understand the biology of cancer. We used matrix-assisted laser …

Detecting, characterizing, and interpreting gene–gene interactions or epistasis in studies of
human disease susceptibility is both a mathematical and a computational challenge. To …