Over a last decade, intense interest has been focused on biomarker discovery and their
clinical uses. This interest is accelerated by the completion of human genome project and …

Lung cancer is the most frequently occurring cancer in the world and continually leads in
mortality among cancers. The overall 5-year survival rate for lung cancer has risen only …

Comparative oncology is a field of study that has been recently adopted for studying cancer
and developing cancer therapies. Companion animals such as dogs can be used to …

The ret/PTC oncogene, a rearranged form of the ret proto-oncogene, has been found to be
restricted to human papillary thyroid carcinomas. This report shows that transgenic mice with …

ABSTRACT Human papillomavirus type 16 (HPV16) and other high-risk HPVs are
etiologically linked to the development of cervical carcinomas and contribute to a number of …

Two major isoforms of the Runx2 gene are expressed by alternative promoter usage: Runx2
type I (Runx2-I) is derived from the proximal promoter (P2), and Runx2 type II (Runx2-II) is …

The ribonuclease (RNase) H class of enzymes degrades the RNA component of RNA: DNA
hybrids and is important in nucleic acid metabolism. RNase H2 is specialized to remove …

Tumor cell invasion is a process regulated by integrins, matrix-degrading enzymes, and
interactions with host tissue stromal cells. The ADAM family of proteins plays an important …

Background. Accurate assessment of treatment efficacy would facilitate clinical trials of new
antituberculosis drugs. We hypothesized that early alterations in peripheral immunity could …

Alkaline phosphatase (ALP) is a widely accepted bone marker. Its expression is stimulated
by bone morphogenetic protein (BMP)-2 treatment, the activation of BMP receptors and R …