The emulsion formulation of propofol (Diprivan) evokes pain on iv injection, although its pH
and osmolality are close to those of blood. The pain induced by serial dilutions of propofol in …

We have studied the intensity and time-course of pain during and after injection into an
isolated vein segment in seven normal subjects of saline or glucose of different osmolalities …

The pressure-diameter relationship of the intact human common carotid artery was studied
in 9 healthy subjects ranging in age between 24 and 34 years. The diameter of the carotid …

Inhalation anaesthetics decrease heart rate in isolated hearts but mostly increase heart rate
in the intact organism, although most inhibit sympathetic drive. Differences in the degree of …

1. To explore the function of the sensory innervation of veins in humans we used a
psychophysical approach to study painful and non‐painful sensations by applying …

We studied the time course of arterial hypotension and/or bradycardia requiring treatment
during spinal anesthesia and compared the efficacy of IV fluid or vasoconstrictor …

Possible development of tachyphylaxis to local anesthetics in the nerve itself (time-
dependent change in axonal conduction properties) was studied in the aortic nerve of eight …

To test the hypothesis that nitric oxide (NO) acts algetically in humans, we determined pain
intensity/dose relations for intracutaneously applied NO solutions. NO, dissolved in …

1. To test the hypothesis that nociceptors of cutaneous veins mediate cold pain, we studied
in man the time course of pain intensity and skin sensibility in relation to both intracutaneous …

Relationships between plasma concentrations of fentanyl and is analgesic, respiratory and
cardiovascular effects were determined in unanesthetized dogs. To avoid drug interactions …