Adenosine receptor activation and nociception
J Sawynok - European journal of pharmacology, 1998 - Elsevier
Adenosine and ATP exert multiple influences on pain transmission at peripheral and spinal
sites. At peripheral nerve terminals in rodents, adenosine A1 receptor activation produces …
sites. At peripheral nerve terminals in rodents, adenosine A1 receptor activation produces …
Adenosine in the spinal cord and periphery: release and regulation of pain
J Sawynok, XJ Liu - Progress in neurobiology, 2003 - Elsevier
In the central nervous system (CNS), adenosine is an important neuromodulator and
regulates neuronal and non-neuronal cellular function (eg microglia) by actions on …
regulates neuronal and non-neuronal cellular function (eg microglia) by actions on …
Topical and peripherally acting analgesics
J Sawynok - Pharmacological reviews, 2003 - ASPET
Acute nociceptive, inflammatory, and neuropathic pain all depend to some degree on the
peripheral activation of primary sensory afferent neurons. The localized peripheral …
peripheral activation of primary sensory afferent neurons. The localized peripheral …
Antidepressants as analgesics: an overview of central and peripheral mechanisms of action.
J Sawynok, MJ Esser, AR Reid - Journal of Psychiatry and …, 2001 - ncbi.nlm.nih.gov
Antidepressants, given systemically, are widely used for the treatment of various chronic and
neuropathic pain conditions in humans. In animal studies, antidepressants exhibit analgesic …
neuropathic pain conditions in humans. In animal studies, antidepressants exhibit analgesic …
On the specificity of naloxone as an opiate antagonist
J Sawynok, C Pinsky, FS LaBella - Life sciences, 1979 - Elsevier
Since the discovery of endogenous opioid peptides in brain (68, 69, 97,113, 128) and the
pituitary gland (26, 81,105,125) there has been considerable interest in their possible roles …
pituitary gland (26, 81,105,125) there has been considerable interest in their possible roles …
Adenosine receptor targets for pain
J Sawynok - Neuroscience, 2016 - Elsevier
The main focus for the development of adenosine targets as analgesics to date has been A
1 Rs due to its antinociceptive profile in various preclinical pain models. The usefulness of …
1 Rs due to its antinociceptive profile in various preclinical pain models. The usefulness of …
Pharmacological rationale for the clinical use of caffeine
J Sawynok - Drugs, 1995 - Springer
Caffeine is widely consumed in beverages to obtain mild CNS stimulant effects. Long term
use produces tolerance to some of the pharmacological effects. Withdrawal of caffeine, even …
use produces tolerance to some of the pharmacological effects. Withdrawal of caffeine, even …
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial
ME Lynch, AJ Clark, J Sawynok… - The Journal of the …, 2005 - pubs.asahq.org
Background A double-blind, randomized, placebo-controlled 3-week study evaluated the
efficacy of topical 2% amitriptyline, 1% ketamine, and a combination of both in treating …
efficacy of topical 2% amitriptyline, 1% ketamine, and a combination of both in treating …
[HTML][HTML] Topical amitriptyline and ketamine in neuropathic pain syndromes: an open-label study
ME Lynch, AJ Clark, J Sawynok, MJ Sullivan - The Journal of Pain, 2005 - Elsevier
Twenty eight subjects with refractory, moderate to severe peripheral neuropathic pain
participated in an open label prospective trial examining perceived analgesic effect, patient …
participated in an open label prospective trial examining perceived analgesic effect, patient …
Caffeine and pain
J Sawynok - PAIN®, 2011 - Elsevier
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