Opioids are the cornerstone therapy for the treatment of moderate to severe pain. Although
common concerns regarding the use of opioids include the potential for detrimental side …

This review summarizes recent findings on peripheral mechanisms underlying the
generation and inhibition of pain. The focus is on events occurring in peripheral injured …

Complex regional pain syndrome (CRPS) is a highly enigmatic syndrome typically
developing after injury or surgery to a limb. Severe pain and disability are common among …

Clinically recorded pain scores are abundant in patient health records but are rarely used in
research. The use of this information could help improve clinical outcomes. For example, a …

Opioid pain medications have detrimental side effects including analgesic tolerance and
opioid-induced hyperalgesia (OIH). Tolerance and OIH counteract opioid analgesia and …

In order to better understand the prevalence of chronic pain and the frequency of analgesic
use in the US veteran general medical population, a review of 300 randomly selected charts …

OBJECTIVE: GABAA receptors play an important regulatory role in the developmental
events leading to the formation of complex neuronal networks and to the behaviors they …

Opioids are the cornerstone medication for the management of moderate to severe pain.
Unfortunately, vast inter-individual differences in dose requirements complicate their …

Background: Inflammation and nociceptive sensitization are hallmarks of tissue surrounding
surgical incisions. Recent studies demonstrate that several cytokines may participate in the …

This investigation used capsaicin to selectively lesion unmyelinated sensory neurons in rats.
Neuronal lesioning induced a loss of trabecular integrity, reduced bone mass and strength …