COVID-19 is a syndrome that includes more than just isolated respiratory disease, as severe
acute respiratory syndrome–coronavirus 2 (SARS-CoV2) also interacts with the …

SoCIETy researchers became focused on altitude effects on humans and other animals.
West5 has written a comprehensive recent review on the history of these early altitude …

Background Dexmedetomidine, a highly selective alpha2-adrenoceptor agonist used for
short-term sedation of mechanically ventilated patients, has minimal effect on ventilation …

New Findings What is the topic of this review? This review provides an up‐to‐date
assessment of the physiology involved with extreme static dry‐land breath holding in trained …

We report three patients undergoing cervical spine surgery who required awake fiberoptic
intubation, and in whom sedation was provided using a dexmedetomidine infusion …

Characterization of the influence of oxygen availability on brain metabolism is an essential
step toward a better understanding of brain energy homoeostasis and has obvious clinical …

Key points Preclinical models have demonstrated that nitric oxide is a key component of
neurovascular coupling; this has yet to be translated to humans. We conducted two separate …

The interindividual variation in ventilatory acclimatization to high altitude is likely reflected in
variability in the cerebrovascular responses to high altitude, particularly between brain …

Cerebral hypoxic vasodilation is poorly understood in humans, which undermines the
development of therapeutics to optimize cerebral oxygen delivery. Across four investigations …

We sought to characterize and quantify the performance of a portable dynamic end-tidal
forcing (DEF) system in controlling the partial pressure of arterial CO2 (PaCO2) and O2 …