Partial peripheral nerve injury leads to activation of astroglia and microglia which parallels the development of allodynic behavior
DE Coyle - Glia, 1998 - Wiley Online Library
Three different cell markers were studied in rats to note changes in the immunoreactivity (IR)
in the lumbar spinal cord 1 to 84 days following partial sciatic nerve ligation (PSNL) …
in the lumbar spinal cord 1 to 84 days following partial sciatic nerve ligation (PSNL) …
The chemokine CXCL1/growth related oncogene increases sodium currents and neuronal excitability in small diameter sensory neurons
JG Wang, JA Strong, W Xie, RH Yang… - Molecular …, 2008 - journals.sagepub.com
Background: Altered Na+ channel expression, enhanced excitability, and spontaneous
activity occur in nerve-injury and inflammatory models of pathological pain, through poorly …
activity occur in nerve-injury and inflammatory models of pathological pain, through poorly …
Female rats are more susceptible to the development of neuropathic pain using the partial sciatic nerve ligation (PSNL) model
DE Coyle, CS Sehlhorst, C Mascari - Neuroscience letters, 1995 - Elsevier
A comparison study was conducted to determine if a gender difference could be detected
using an animal model for causalgia. The sciatic nerve was tightly ligated so that 1 3 to 1 2 of …
using an animal model for causalgia. The sciatic nerve was tightly ligated so that 1 3 to 1 2 of …
Cardiovascular toxicity of local anesthetics: an alternative hypothesis
RD Thomas, MM Behbehani, DE Coyle… - Anesthesia & …, 1986 - journals.lww.com
The current study examined the possibility that high local anesthetic concentrations within
the central nervous system could contribute to the toxic cardiovascular effects observed …
the central nervous system could contribute to the toxic cardiovascular effects observed …
[HTML][HTML] Microarray analysis of rat sensory ganglia after local inflammation implicates novel cytokines in pain
Inflammation plays a role in neuropathic pain conditions as well as in pain induced solely by
an inflammatory stimulus. Robust mechanical hyperalgesia and allodynia can be induced by …
an inflammatory stimulus. Robust mechanical hyperalgesia and allodynia can be induced by …
[PDF][PDF] Bupivacaine and lidocaine blockade of calcium-mediated slow action potentials in guinea pig ventricular muscle.
DE Coyle, N Sperelakis - Journal of Pharmacology and Experimental …, 1987 - Citeseer
The effects of bupivacaine and Ildocalne on the slow-nsing action potentials, induced by
superfusion with high-K (26 mM) Ty-rode's solution with 1 0 M isoproterenol, were studied in …
superfusion with high-K (26 mM) Ty-rode's solution with 1 0 M isoproterenol, were studied in …
Pharmacokinetics of hydromorphone after intravenous, peroral and rectal administration to human subjects
PV Parab, WA Ritschel, DE Coyle… - … & drug disposition, 1988 - Wiley Online Library
The pharmacokinetic properties of hydromorphone in healthy young male subjects were
studied after iv, peroral, and rectal administration. After iv administration the following …
studied after iv, peroral, and rectal administration. After iv administration the following …
[HTML][HTML] Regional differentiation of retinoic acid-induced human pluripotent embryonic carcinoma stem cell neurons
The NTERA2 cl D1 (NT2) cell line, derived from human teratocarcinoma, exhibits similar
properties as embryonic stem (ES) cells or very early neuroepitheial progenitors. NT2 cells …
properties as embryonic stem (ES) cells or very early neuroepitheial progenitors. NT2 cells …
Antibiotic-impregnated catheters associated with significant decrease in nosocomial and multidrug-resistant bacteremias in critically ill patients
HA Hanna, II Raad, B Hackett, SK Wallace, KJ Price… - Chest, 2003 - Elsevier
Objective: To evaluate the impact of using central venous catheters (CVCs) impregnated
with the combination of minocycline and rifampin on nosocomial bloodstream infections …
with the combination of minocycline and rifampin on nosocomial bloodstream infections …
Absolute bioavailability of hydromorphone after peroral and rectal administration in humans: saliva/plasma ratio and clinical effects
WA Ritschel, PV Parab, DD Denson… - The Journal of …, 1987 - Wiley Online Library
The absolute bioavailability of hydromorphone was investigated in eight healthy male
subjects by a cross‐over design (with washout period of two weeks) after intravenous (2 mgj …
subjects by a cross‐over design (with washout period of two weeks) after intravenous (2 mgj …