The development and maintenance of chronic neuropathic pain involves distorted neuroglial
interactions, which result in prolonged perturbations of immune and inflammatory response …

Glial cells play an essential role in maintaining the proper functioning of the nervous system.
They are more abundant than neurons in most neural tissues and provide metabolic and …

Spinal cord stimulation is a proven effective therapy for treating chronic neuropathic pain.
Previous work in our laboratory demonstrated that spinal cord stimulation based on a …

Background: Radiofrequency (RF) ablation for denervation has been utilized for decades in
chronic pain management. This relies on the proper targeting of the affected nerve which …

Background Few studies have evaluated single-gene changes modulated by spinal cord
stimulation (SCS), providing a narrow understanding of molecular changes. Genomics …

While numerous studies and patient experiences have demonstrated the efficacy of spinal
cord stimulation as a treatment for chronic neuropathic pain, the exact mechanism …

Objective To investigate the effect of phase polarity and charge balance of spinal cord
stimulation (SCS) waveforms on pain behavior and gene expression in a neuropathic pain …

Objectives Spinal cord stimulation (SCS) provides relief for patients suffering from chronic
neuropathic pain although its mechanism may not be as dependent on electrical …

Background and Objectives Radiofrequency (RF) neuroablation is a common therapy for
alleviating chronic pain. Larger lesion volumes lead to higher chance of ablating small …

Objectives Rats are commonly used for translational pain and spinal cord stimulation (SCS)
research. Although many SCS parameters are configured identically between rats and …