The regulator of G protein signaling family
L De Vries, B Zheng, T Fischer, E Elenko… - Annual review of …, 2000 - annualreviews.org
Regulator of G protein signaling (RGS) proteins are responsible for the rapid turnoff of G
protein–coupled receptor signaling pathways. The major mechanism whereby RGS proteins …
protein–coupled receptor signaling pathways. The major mechanism whereby RGS proteins …
Recent advances and clinical applications of deep learning in medical image analysis
Deep learning has received extensive research interest in developing new medical image
processing algorithms, and deep learning based models have been remarkably successful …
processing algorithms, and deep learning based models have been remarkably successful …
Malaria in the Greater Mekong Subregion: heterogeneity and complexity
The Greater Mekong Subregion (GMS), comprised of six countries including Cambodia,
China's Yunnan Province, Lao PDR, Myanmar (Burma), Thailand and Vietnam, is one of the …
China's Yunnan Province, Lao PDR, Myanmar (Burma), Thailand and Vietnam, is one of the …
[PDF][PDF] AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
YU Li, S Xu, MM Mihaylova, B Zheng, X Hou, B Jiang… - Cell metabolism, 2011 - cell.com
AMPK has emerged as a critical mechanism for salutary effects of polyphenols on lipid
metabolic disorders in type 1 and type 2 diabetes. Here we demonstrate that AMPK interacts …
metabolic disorders in type 1 and type 2 diabetes. Here we demonstrate that AMPK interacts …
[HTML][HTML] Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions
J Du, X Wang, C Miereles, JL Bailey… - The Journal of …, 2004 - Am Soc Clin Investig
With trauma, sepsis, cancer, or uremia, animals or patients experience accelerated
degradation of muscle protein in the ATP-ubiquitin-proteasome (Ub-P'some) system. The …
degradation of muscle protein in the ATP-ubiquitin-proteasome (Ub-P'some) system. The …
PGC-1α, A Potential Therapeutic Target for Early Intervention in Parkinson's Disease
B Zheng, Z Liao, JJ Locascio, KA Lesniak… - Science translational …, 2010 - science.org
Parkinson's disease affects 5 million people worldwide, but the molecular mechanisms
underlying its pathogenesis are still unclear. Here, we report a genome-wide meta-analysis …
underlying its pathogenesis are still unclear. Here, we report a genome-wide meta-analysis …
N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2
SARS-CoV-2 has been spreading around the world for the past year. Recently, several
variants such as B. 1.1. 7 (alpha), B. 1.351 (beta), and P. 1 (gamma), which share a key …
variants such as B. 1.1. 7 (alpha), B. 1.351 (beta), and P. 1 (gamma), which share a key …
Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease
MM Lipinski, B Zheng, T Lu, Z Yan… - Proceedings of the …, 2010 - National Acad Sciences
Dysregulation of autophagy, a cellular catabolic mechanism essential for degradation of
misfolded proteins, has been implicated in multiple neurodegenerative diseases. However …
misfolded proteins, has been implicated in multiple neurodegenerative diseases. However …
[PDF][PDF] AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1
Thioredoxin-interacting protein (TXNIP) is an α-arrestin family protein that is induced in
response to glucose elevation. It has been shown to provide a negative feedback loop to …
response to glucose elevation. It has been shown to provide a negative feedback loop to …
Improving the performance of CNN to predict the likelihood of COVID-19 using chest X-ray images with preprocessing algorithms
M Heidari, S Mirniaharikandehei, AZ Khuzani… - International journal of …, 2020 - Elsevier
Objective This study aims to develop and test a new computer-aided diagnosis (CAD)
scheme of chest X-ray images to detect coronavirus (COVID-19) infected pneumonia …
scheme of chest X-ray images to detect coronavirus (COVID-19) infected pneumonia …