Paclitaxel, an effective anti-neoplastic agent in the treatment of solid tumors, produces a
dose-limiting painful peripheral neuropathy in a clinically significant number of cancer …

The idea of selectively targeting nociceptive transmission at the level of the peripheral
nervous system is attractive from multiple perspectives, particularly the potential lack of non …

Control of cancer, neuropathic, and postoperative pain is frequently inadequate or
compromised by debilitating side effects. Inhibition or removal of certain nociceptive …

Background and Objectives: Radiofrequency (RF) denervation of the sacroiliac (SI) joint has
been advocated for the treatment of sacroiliac syndrome, yet no clinical studies or case …

Background Resiniferatoxin is a potent capsaicin analog. Intrathecal administration leads to
selective, prolonged opening of the transient receptor potential V1 ion channel, which is …

Disorders of pain neural systems are frequently chronic and, when recalcitrant to treatment,
can severely degrade the quality of life. The pain pathway begins with sensory neurons in …

The powerful endogenous morphine, as the namedynorphin'signifies, was isolated
approximately a quarter century ago by Avram Goldstein's group at Stanford (Goldstein et …

One of the biggest challenges for analgesic drug development is how to decide if a potential
analgesic candidate will work in humans. What preclinical data are the most convincing …

Chronic pain and itch are common hypersensitivity syndromes that are affected by
endogenous mediators. We applied a systems-based, translational approach to predict …

Background The trigeminal ganglion contains neurons that relay sensations of pain, touch,
pressure, and many other somatosensory modalities to the central nervous system. The …