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Activin A induces a non-fibrotic phenotype in smooth muscle cells in contrast to TGF-β.
Groenendijk BC, Benus GF, Klous A, Pacheco YM, Volger OL, Fledderus JO, Ferreira V, Engelse MA, Pannekoek H, ten Dijke P, Horrevoets AJ, de Vries CJ. Groenendijk BC, et al. Among authors: klous a. Exp Cell Res. 2011 Jan 15;317(2):131-42. doi: 10.1016/j.yexcr.2010.10.007. Epub 2010 Oct 15. Exp Cell Res. 2011. PMID: 20955695
p27kip1-838C>A single nucleotide polymorphism is associated with restenosis risk after coronary stenting and modulates p27kip1 promoter activity.
van Tiel CM, Bonta PI, Rittersma SZ, Beijk MA, Bradley EJ, Klous AM, Koch KT, Baas F, Jukema JW, Pons D, Sampietro ML, Pannekoek H, de Winter RJ, de Vries CJ. van Tiel CM, et al. Among authors: klous am. Circulation. 2009 Aug 25;120(8):669-76. doi: 10.1161/CIRCULATIONAHA.108.842179. Epub 2009 Aug 10. Circulation. 2009. PMID: 19667240
Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers.
Ruivenkamp CA, van Wezel T, Zanon C, Stassen AP, Vlcek C, Csikós T, Klous AM, Tripodis N, Perrakis A, Boerrigter L, Groot PC, Lindeman J, Mooi WJ, Meijjer GA, Scholten G, Dauwerse H, Paces V, van Zandwijk N, van Ommen GJ, Demant P. Ruivenkamp CA, et al. Among authors: klous am. Nat Genet. 2002 Jul;31(3):295-300. doi: 10.1038/ng903. Epub 2002 Jun 24. Nat Genet. 2002. PMID: 12089527