Neurotoxic manifestations of an overdose intrathecal injection of gadopentetate dimeglumine

J Korean Med Sci. 2010 Mar;25(3):505-8. doi: 10.3346/jkms.2010.25.3.505. Epub 2010 Feb 17.

Abstract

The intravenous administration of gadopentetate dimeglumine (GD) is relatively safe and rarely causes systemic toxicity in the course of routine imaging studies. However, the general safety of intrathecal GD has not been established. We report a very rare case of an overdose intrathecal GD injection presenting with neurotoxic manifestations, including a decreased level of consciousness, global aphasia, rigidity, and visual disturbance.

Keywords: Gadolinium DTPA; Injections, Spinal; Neurologic Manifestations.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aphasia / etiology
  • Aphasia / pathology
  • Aphasia / physiopathology
  • Brain / drug effects
  • Brain / pathology
  • Contrast Media* / administration & dosage
  • Contrast Media* / toxicity
  • Gadolinium DTPA* / administration & dosage
  • Gadolinium DTPA* / toxicity
  • Humans
  • Injections, Spinal*
  • Male
  • Muscle Rigidity / etiology
  • Muscle Rigidity / pathology
  • Muscle Rigidity / physiopathology
  • Neurotoxicity Syndromes* / etiology
  • Neurotoxicity Syndromes* / pathology
  • Neurotoxicity Syndromes* / physiopathology
  • Tomography, X-Ray Computed
  • Vision Disorders / etiology
  • Vision Disorders / pathology

Substances

  • Contrast Media
  • Gadolinium DTPA