Open Access, Peer-reviewed
eISSN 2093-758X
    J Korean Acad Nurs. 2009 Feb;39(1):44-52. Korean.
    Published online Feb 28, 2009.
    https://doi.org/10.4040/jkan.2009.39.1.44
    Copyright © 2009 Korean Society of Nursing Science
    Original Article

    Effect of Ondansetron combined with Dexamethasone on Postoperative Nausea & Vomiting and Pain of Patients with Laparoscopic Hysterectomy

    Miok Nam,1 and Haesang Yoon2
      • 1Head Nurse, Department of Nursing, Gil Medical Center, Incheon, Korea.
      • 2Professor, Department of Nursing, Gachon University of Medicine & Science, Incheon, Korea.
    • Address reprint requests to: Yoon, Haesang. Department of Nursing, Gachon University of Medicine & Science, 534-2 Yeonsu-dong, Yeonsu-gu, Incheon 406-812, Korea. Tel: 82-32-820-4212, Fax: 82-32-820-4201, Email: hsyoon@gachon.ac.kr
    Received May 07, 2008; Accepted January 14, 2009.

    Abstract

    Purpose

    The purpose of this study was to compare the effects of ondansetron combined with dexamethasone on Post-Operative Nausea and Vomiting (PONV) and pain with ondansetron alone in patients with laparoscopy assisted vaginal hysterectomy under general anesthesia.

    Methods

    Data were collected from April 1 through September 30, 2005 using a double blind method. Ondansetron 4 mg and dexamethasone 10 mg were administered to the experimental group (25 patients), and ondansetron 4 mg only to the control group (25 patients). The medications were administered through an intravenous line at the beginning peritoneum suture. PONV by Index of Nausea Vomiting and Retching (INVR), nausea by Visual Analogue Scale (VAS), and pain (VAS) were assessed at postoperative 1 hr, 3 hr, 6 hr, 24 hr, and 48 hr. Data were analyzed using repeated measures ANOVA, and Bonferroni methods.

    Results

    The experimental group that received ondansetron combined with dexamethasone had less PONV (p=.048), and nausea (p=.012) than control group that received ondansetron alone. However, there was no difference in pain (p=.557) between the patients in the two groups.

    Conclusion

    We conclude that the administration of ondansetron combined with dexamethasone is more effective than the administration of ondansetron alone to reduce PONV in patients with laparoscopic hysterectomy.

    Keywords
    Ondansetron; Dexamethasone; Postoperative nausea and vomiting; Postoperative pain

    Tables

    Table 1
    Homogeneity Test for General Characteristics (N=50)

    Table 2
    Homogeneity Test for Physiological Characteristics (N=50)

    Table 3
    Nausea and Vomiting (N=50)

    Table 4
    Pain (N=50)

    Table 5
    Frequency of Administration of Antiemetics, Analgesics, and Pushing PCA Button for Postoperative 24 hr

    Notes

    This study is a part of Master's thesis.

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    MeSH Terms
    Hysterectomy, Vaginal*
    Adult
    Analgesia, Patient-Controlled
    Analysis of Variance
    Anesthesia, General
    Antiemetics/administration & dosage*
    Data Interpretation, Statistical
    Dexamethasone/administration & dosage*
    Double-Blind Method
    Drug Therapy, Combination
    Female
    Humans
    Laparoscopy
    Middle Aged
    Ondansetron/administration & dosage*
    Pain/drug therapy*
    Postoperative Nausea and Vomiting/drug therapy*
    Postoperative Period
    Time Factors
    Metrics
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