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Intrathecal morphine-3-glucuronide-induced nociceptive behavior via Delta-2 opioid receptors in the spinal cord
2016, Pharmacology Biochemistry and BehaviorCitation Excerpt :Similarly, dynorphin A(2–17) (3 nmol, i.t.) in mice also induced allodynia (Laughlin et al., 1997; Vanderah et al., 1996a). Pain-related behavior associated with nerve injury is also blocked by an antiserum to dynorphin (Bian et al., 1999; Malan et al., 2000; Wagner and Deleo, 1996; Wang et al., 2001). Dynorphin-converting enzymes, belonging to the cysteine protease family, cleave dynorphin A and dynorphin B between Leu5–Arg6 and Arg6–Arg7 bonds, thereby generating leucine-enkephalin (Leu-ENK) and Leu-ENK-Arg, which are primarily active in δ-opioid receptors (Silberring et al., 1992).
Chapter 16 Mechanism of Allodynia Evoked by Intrathecal Morphine-3-Glucuronide in Mice
2009, International Review of NeurobiologyCitation Excerpt :High doses of dynorphin produce hyperalgesia and allodynia, in contrast to analgesia produced by low doses of dynorphin (Laughlin et al., 1997; Vanderah et al., 1996). Pain‐related behavior associated with nerve injury is also blocked by antiserum to dynorphin (Bian et al., 1999; Malan et al., 2000; Wagner and Deleo, 1996; Wang et al., 2001). The hyperalgesic effect is considered to be independent of the activation of opioid receptors.
Chapter 15 Nociceptive Behavior Induced by the Endogenous Opioid Peptides Dynorphins in Uninjured Mice. Evidence with Intrathecal N-Ethylmaleimide Inhibiting Dynorphin Degradation
2009, International Review of NeurobiologyCitation Excerpt :Another set of evidence supports the notion on the pronociceptive functions of dynorphin A in the spinal cord. Behavioral hyperalgesia as a result of inflammation or tissue injury is accompanied by elevations in spinal dynorphin content (Draisci et al., 1991; Dubner and Ruda, 1992; Iadarola et al., 1988; Kajander et al., 1990; Malan et al., 2000; Riley et al., 1996; Ruda et al., 1988; Wagner and Deleo, 1996). This increase is considered as causative of hyperalgesia and allodynia.
Spinal Dynorphin and Bradykinin Receptors Maintain Inflammatory Hyperalgesia
2008, Journal of PainPronociceptive actions of dynorphin via bradykinin receptors
2008, Neuroscience Letters