Prescribing information of different brands of gadolinium23
Trade name | Generic name | Structure | Documents the risk of serious nervous system-related complications? | Presents information regarding intrathecal injection? | Molar concentration of gadolinium (mol/L) |
Ablavar58 | Gadofosveset trisodium | Linear ionic | No | No | 0.25 |
Dotarem59 | Gadoterate meglumine | Macrocyclic ionic | Yes | No | 0.5 |
Eovist60 | Gadoxetate disodium | Linear ionic | Yes | No | 0.25 |
Gadavist61 | Gadobutrol | Macrocyclic nonionic | Yes | No | 1 |
Magnevist62 | Gadopentetate dimeglumine | Linear ionic | Yes | No | 0.5 |
MultiHance63 | Gadobenate dimeglumine | Linear ionic | Yes | No* | 0.5 |
Omniscan64 | Gadodiamide | Linear non-ionic | Yes† | Yes‡ | 0.5 |
Optimark65 | Gadoversetamide | Linear non-ionic | Yes | No* | 0.5 |
ProHance66 | Gadoteridol | Macrocyclic non-ionic | Yes | No | 0.5 |
*States that it is only for intravenous use.
†Specifically indicates the risk of neurotoxicity due to intrathecal administration.
‡States: ‘Not for intrathecal use. Inadvertent intrathecal use of gadodiamide has occurred and caused convulsions, coma, sensory and motor neurologic deficits.’