Bupivacaine | Ropivacaine | |||||
All | PVB | TAP | All | PVB | TAP | |
Bolus dosing | ||||||
Concentration (%) | 0.25 (0.125–0.5) n=2724 | 0.27 (0.125–0.5) N=2250 | 0.25 (0.125–0.375) N=474 | 0.5 (0.2–0.75), n=2978 | 0.5 (0.2–0.75), n=2518 | 0.5 (0.1–1.0), n=460 |
Volume (mL) | 20 (6.5–60) N=2236 | 20 (8–60) N=1972 | 30 (5–40) N=264 | 20 (10–60), n=2581 | 20 (10–50), n=2140 | 30 (17.5–100), n=441 |
Weight-based volume (mL/kg) | 0.4 (0.1–1.6) N=488 | 0.3 (0.1–0.4) N=278 | 0.4 (0.4–0.8) N=210 | 0.3 (0.1–0.4), n=397 | 0.3 (0.1–0.4), n=378 | 0.4 (0.4–0.4), n=19 |
Overall bolus dosing (calculated) | ||||||
Median dose (mg/kg) | 1.0 (0.18–2.1) N=2724 | 1.0 (0.23–2.1) N=2250 | 1.0 (0.14–2.0) N=474 | 1.4 (0.4–3.0), n=2978 | 1.3 (0.43–2.5), n=2518 | 2.1 (0.6–4.3), n=460 |
IQR (mg/kg) | 0.7–1.4 | 0.7–1.4 | 0.8–1.4 | 0.8–2.1 | 0.8–2.1 | 1.0–2.9 |
90th percentile dose (mg/kg) | 1.75 | 1.7 | 2.0 | 2.4 | 2.1 | 3.0 |
Mean±SD (mg/kg) | 1.1±0.5 | 1.1±0.5 | 1.1±0.5 | 1.5±0.76 | 1.4±0.7 | 2.0±1.0 |
Unless otherwise specified, data presented as median (95% CI), n.
PVB, paravertebral; TAP, transversus abdominis plane.