Table 2

Infusion dosing characteristics

	Bupivacaine			Ropivacaine
	All	PVB	TAP	All	PVB	TAP
Continuous infusion parameters
Concentration (%)	0.25 (0.1–0.5) n=2723	0.25 (0.1–0.5) n=2529	0.2 (0.125–0.25) n=194	0.2 (0.075–0.6) n=3197	0.2 (0.075–0.6), n=2772	0.2 (0.1–0.35), n=425
Rate per hour (mL/hour)	6 (3–20) n=2080	6 (4–20) n=1906	10 (2–14) n=174	9 (3–22), n=2520	7 (3–22), n=2099	10 (2–25), n=421
Weight-based rate (mL/kg/hour)	0.1 (0.05–0.4) n=661*	0.1 (0.05–0.4) n=641	0.2 (0.2–0.2) n=20	0.1 (0.1–0.3), n=933†	0.1 (0.1–0.3), n=929	0.2 (0.2–0.2), n=4
Intermittent bolus dosing
Concentration (%)	0.25 (0.125–0.5) n=476	0.5 (0.25–0.5) n=151	0.25 (0.125–0.375) n=325	0.2 (0.2–0.75), n=365	0.2 (0.2–0.375), n=271	0.5 (0.2–0.75), n=94
Volume (mL)	20 (10–40) n=309	15 (10–20) n=136	20 (20–40) n=173	15 (5–40), n=346	10 (6–15), n=271	18 (18–40), n=75
Vol dose (mL/kg)	0.4 (0.3–0.53) n=167	0.3 (0.3–0.3) n=15	0.4 (0.4–0.53) n=152	0.4 (0.4–0.4), n=19		0.4 (0.4–0.4), n=19
Interval (hours)	8 (3–12) n=476	6 (3–12) n=151	8 (8–12) n=325	6 (1–12), n=365	6 (1–6), n=271	4 (4–12), n=94
Overall infusion dosing (calculated)
Median dose (mg/kg/hour)	0.20 (0.06–0.5) n=3199	0.23 (0.07–0.5) n=2680	0.125 (0.06–0.36) n=519	0.26 (0.06–0.63), n=3579	0.23 (0.06–0.63), n=3060	0.32 (0.06–0.51), n=519
IQR (mg/kg/hour)	0.14–0.31	0.18–0.36	0.1–0.2	0.15–0.43	0.15–0.43	0.23–0.36
90th percentile dose (mg/kg/hour)	0.43	0.45	0.25	0.54	0.59	0.46
Mean±SD (mg/kg/hour)	0.24±0.12	0.26±0.12	0.15±0.07	0.3±0.17	0.3±0.18	0.3±0.1

Unless otherwise specified, data presented as median (95% CI), n.
*For 18 patients in Garutti et al,49 both a volume by hour and volume by weight were reported.
†A total of 256 patients from Boezaart et al120 were reported with both a volume per hour and weight-based volume per hour. Rounded to the closest 0.05.
PVB, paravertebral; TAP, transversus abdominis plane.