Table 3

Breakthrough and 24-hour dosing characteristics

	Bupivacaine			Ropivacaine
	All	PVB	TAP	All	PVB	TAP
24-hour breakthrough dosing
Breakthrough mean (mg/kg)	0.14 (0.03–1.3) n=385	0.14 (0.03–1.3) n=354	0.29 (0.25–0.45) n=31	0.27 (0.05–2.3), n=1109	0.43 (0.05–2.3), n=996	0.14 (0.06–0.3), n=113
Breakthrough max (mg/kg)	0.29 (0.07–2.8) n=385	0.29 (0.07–2.8) n=354	0.29 (0.25–0.9) n=31	1.7 (0.12–7.2), n=1109	1.5 (0.1–7.2), n=996	3.1 (0.15–6.9), n=113
24-hour total doses (Bolus, infusion and breakthrough)
Median 24-hour dose (mg/kg)	6 (2.1–13.6) N=3223	6.1 (2.5–13.6) n=2700	4 (1.5–10) n=523	7.75 (2.1–15.7), n=3579	7.3 (2.1–15.9), n=3060	8.0 (2.2–15.1), n=519
IQR (mg/kg)	4.1–9.6	5.0–9.6	3.2–6.8	6.1–11.1	5.8–11.1	7.7–12.4
Mean±SD (mg/kg)	6.6±3.2	7.0±3.2	4.7±2.2	8.4±3.8	8.3±3.8	9.0±3.5