Ropivacaine | Bupivacaine | |||||

All | <6 months | >6 months | All | <6 months | >6 months | |

Continuous infusion details (reported) | ||||||

Concentration (%) | 0.2 (0.05–0.5) (n=521) | 0.5 (0.05–0.5) (n=53) | 0.2 (0.1–0.2) (n=468) | 0.25 (0.0625–0.5) (n=417) | 0.1 (0.0625–0.25) (n=88) | 0.25 (0.1–0.5) (n=329) |

Rate per hour (mL/hour) | 5 (1–18) (n=26) | 1.0 (1.0–2.5) (n=5) | 6.1 (2–18) (n=21) | 4 (1.5–8) (n=14) | – | 4 (1.5–8) (n=144) |

Weight-based rate (mL/kg/hour) | 0.25 (0.1–0.3) (n=495) | 0.1 (0.1–0.3) (n=48) | 0.25 (0.1–0.25) (n=447) | 0.25 (0.1–0.4) (n=275) | 0.3 (0.2–0.36) (n=88) | 0.25 (0.1–0.4) (n=187) |

Intermittent bolus details (reported) | ||||||

Concentration (%) | – | – | – | 0.1625 (0.1–0.25) (n=6) | 0.1 (0.1–0.25) (n=3) | 0.2 (0.125–0.25) (n=3) |

Volume (mL) | – | – | – | 5.5 (5-6) (n=3) | 5 (n=1) | 6 (n=2) |

Volume by weight (mL/kg) | – | – | – | 1 (n=3) | 1 (n=2) | 1 (n=1) |

Interval (hours) | – | – | – | 10 (4–12) (n=6) | 12 (8–12) (n=3) | 8 (4–12) (n=3) |

Total infusion dose (calculated) | ||||||

Median dose (mg/kg/hour) | 0.5 (0.2–0.68) (n=521) | 0.5 (0.2–0.56) (n=53) | 0.5 (0.2–0.68) (n=468) | 0.33 (0.1–1.0) (n=423) | 0.25 (0.1–0.5) (n=91) | 0.35 (0.12–1.0) (n=332) |

IQR (mg/kg/hour) | 0.3–0.5 | 0.2–0.5 | 0.3–0.5 | 0.25–0.35 | 0.23–0.3 | 0.3–0.35 |

90th percentile dose (mg/kg/hour) | 0.5 | 0.5 | 0.5 | 0.62 | 0.62 | 0.5 |

Unless otherwise specified, data are presented as median (range), n.