Table 3

Cases of LAST and toxic blood levels

PublicationAgeWeightBolus (mg/kg)/infusion (mg/kg/hour)24-hour dose (mg/kg)SurgeryPeak time (hours)/concentration (mg/L)Symptoms
LAST
Bitarafan481 year9.4 kg2.5/0.514.5Thoracoabdominal surgeryPostoperative day 1, NRSeizure following chloroprocaine breakthrough
Toxic blood levels
Cheung et al251.5 weeks (0.1–20.4)3.2 kg (2.5–5.5)1.25/0.257.25MBTS, COARC, plication of diaphragm, pulmonary artery banding30/3.29NR
42 3.14
48/3.21
Karmakar et al2711 months10 kg1.25/0.514Thoracotomy for possible aortopulmonary collateral ligation53/2.81NR
Karmakar et al55.3 weeks (0.3–20.0)3.8 kg
(2.5–6.2)
1.25/0.513.25PDA ligation, MBTS, COARC24/3.14NR
  • COARC, coarctation repair; LAST, local anesthetic systemic toxicity; MBTS, modified Blalock-Taussig shunt repair; NR, not recorded; PDA, patent ductus arteriosus.