Publication | Age | Weight | Bolus (mg/kg)/infusion (mg/kg/hour) | 24-hour dose (mg/kg) | Surgery | Peak time (hours)/concentration (mg/L) | Symptoms |
LAST | |||||||
Bitarafan48 | 1 year | 9.4 kg | 2.5/0.5 | 14.5 | Thoracoabdominal surgery | Postoperative day 1, NR | Seizure following chloroprocaine breakthrough |
Toxic blood levels | |||||||
Cheung et al25 | 1.5 weeks (0.1–20.4) | 3.2 kg (2.5–5.5) | 1.25/0.25 | 7.25 | MBTS, COARC, plication of diaphragm, pulmonary artery banding | 30/3.29 | NR |
42 3.14 | |||||||
48/3.21 | |||||||
Karmakar et al27 | 11 months | 10 kg | 1.25/0.5 | 14 | Thoracotomy for possible aortopulmonary collateral ligation | 53/2.81 | NR |
Karmakar et al5 | 5.3 weeks (0.3–20.0) | 3.8 kg (2.5–6.2) | 1.25/0.5 | 13.25 | PDA ligation, MBTS, COARC | 24/3.14 | NR |
COARC, coarctation repair; LAST, local anesthetic systemic toxicity; MBTS, modified Blalock-Taussig shunt repair; NR, not recorded; PDA, patent ductus arteriosus.