Table 1

Comparison between POD@MN and 24i methods among opioid tolerant, opioid naïve, and all cases

Time interval	Median morphine milligram equivalent			P value
Time interval	POD@MN	24i	Differences	P value
All cases
’POD 0 to 1’ vs ‘0 to 24 hours’	159.9	132.5	−20.5	<0.001
‘POD 0 to 2’ vs ‘0 to 48 hours’	210.4	195.6	−15.0	<0.001
‘POD 1’ vs ‘0 to 24 hours’	90.6	132.5	35.9	<0.001
‘POD 1 to 2’ vs ‘0 to 48 hours’	142.5	195.6	44.7	<0.001
Opioid-tolerant cases
‘POD 0 to 1’ vs ‘0 to 24 hours’	278.5	212.0	−35.3	<0.001
‘POD 0 to 2’ vs ‘0 to 48 hours’	360.7	343.2	−30.0	<0.001
‘POD 1’ vs ‘0 to 24 hours’	173.2	212.0	48.6	<0.001
‘POD 1 to 2’ vs ‘0 to 48 hours’	287.8	343.2	45.2	<0.01
Opioid-naïve cases
‘POD 0 to 1’ vs ‘0 to 24 hours’	144.6	123.8	−17.1	<0.001
‘POD 0 to 2’ vs ‘0 to 48 hours’	185.6	176.7	−7.5	<0.001
‘POD 1’ vs ‘0 to 24 hours’	72.0	123.8	35.3	<0.001
‘POD 1 to 2’ vs ‘0 to 48 hours’	116.1	176.7	44.3	<0.001

In POD@MN, POD 0 begins at procedure stop time and POD 1 begins at midnight following the date of surgery. In 24i, opioid consumption is reported in 24-hour intervals beginning at anesthesia stop time. Time points ‘POD 1’ and ‘0 to 24 hours’ each cover a total of 24 hours. Time points ‘POD 1 to 2’ and ‘0 to 48 hours’ each cover a total of 48 hours. Time point ‘POD 0 to 1’ covers a variable amount of time due to POD 0, as cases ended at different times of the day. P values were calculated using the Wilcoxon matched-pairs signed-rank test.
24i, 24-hour intervals after surgery; POD, postoperative day; POD@MN, postoperative day beginning at midnight following the date of surgery.