Table 1

Details of included studies

StudyInterventionApplication modalityAdditional anesthesiaType of surgerySponsoring/Funding
Liposomal bupivacaineBupivacaine HCl
Alijanipour et al 21 266 mg liposomal bupivacaine*50 mg bupivacaine hydrochloride*PAISpinal anesthesia (15 mg bupivacaine hydrochloride)TKANo financial funding
Alter et al 22 133 mg liposomal bupivacaine+50 mg bupivacaine hydrochloride100 mg bupivacaine hydrochlorideLocal infiltration injection siteGeneral anesthesiaDistal radius repairStudy was supported through an unrestricted educational grant from Pacira Pharmaceuticals
Barron et al 23 266 mg liposomal bupivacaine50 mg bupivacaine hydrochlorideInfiltration at fascial level around the planned throcar siteGeneral anesthesiaLaparascopic hysterectomyNo financial funding
Bramlett et al 24 133 and 266 mg liposomal bupivacaine hydrochloride150 mg bupivacaine hydrochloride*Wound infiltrationGeneral anesthesiaTKASupport by Pacira Pharmaceuticals, one author is paid employe by Pacira Pharmaceuticals
Bultema et al 25 53.2 mg liposomal bupivacaine20 mg bupivacaine hydrochloride*Wound infiltrationInferior alveolar nerve block (lidocaine)Dental interventionNo financial funding
Dale et al 27 266 mg liposomal bupivacaine75 mg bupivacaine hydrochlorideTrapeziometacarpal suspension arthroplasty: subcutaneous infiltration and injection into the neo-joint; proximal row carpectomy: subcutaneous injectionGeneral anesthesiaTrapeziometacarpal suspension arthroplasty or proximal row carpectomyThe liposomal bupivacaine used in the study was donated by Pacira Pharmaceuticals
Glenn et al 26 53.2 mg liposomal bupivacaine20 mg bupivacaine hydrochloride*Buccal infiltrationLocal anesthesia (lidocaine)Dental interventionSupported by a research grant from the American Association of Endodontists Foundation
Ha et al 28 266 mg liposomal bupivacaine75 mg bupivacaine hydrochloride*TAPGeneral anesthesiaAbdominally based autologous microvascular breast reconstructionGrant from hospital foundation, no industrial sponsorship, one author received unrelated founding
Haas et al 29 66, 199, 266 mg liposomal bupivacaine75 mg bupivacaine hydrochloride*Perianal tissue infiltrationGeneral anesthesiaHemorrhoidectomySupported by Pacira Pharmaceuticals
Hutchins et al 30 133 mg liposomal bupivacaine75 mg bupivacaine hydrochloride*Subcostal TAPGeneral anesthesiaHysterectomyGrant funding from Pacira Pharmaceuticals
Hutchins et al 31 133 mg liposomal bupivacaine75 mg bupivacaine hydrochloride*Subcostal TAPGeneral anesthesiaLaparoscopic donor nephrectomyConsultant for Pacira Pharmaceuticals
Iwanoff and Salamon32 266 mg liposomal bupivacaine150 mg bupivacaine hydrochloride+500 mg lidocaineInfiltration of the vaginal subepithelial tissueGeneral anesthesiaMidurethral sling surgeryNo financial funding
Knight et al 33 266 mg liposomal bupivacaineUpto 150 mg bupivacaine hydrochlorideInjection of the laparoscopic port sitesGeneral anesthesiaLaparoscopic urological surgeryNo financial funding
Knudson et al 34 266 mg liposomal bupivacaine150 mg bupivacaine hydrochloride*Subfascial peri-incisional injectionGeneral anesthesiaElective colon resectionNo financial funding
Motakef et al 35 133 mg liposomal bupivacaine50 mg bupivacaine hydrochloride*Field block of breast pocketGeneral anesthesiaBreast reconstructionFunding from Plastic Surgery Foundation
Nadeau et al 36 133 mg liposomal bupivacaine50 mg bupivacaine hydrochloride*Infiltration of breast pocketGeneral anesthesiaBreast augmentationFunding by a resident research grant from Riverside Methodist Hospital
Perets et al 37 266 mg liposomal bupivacaine+100 mg bupivacaine*150 mg bupivacaine hydrochloride*PAIGeneral anesthesiaTotal hip replacementResearch support from Pacira Inc
Premkumar et al 38 266 mg liposomal bupivacaine100 mg bupivacaine hydrochlorideLocal injection into graft harvest site and portal sitesGeneral anesthesiaAnterior cruciate ligament reconstructionNo financial funding
Schroer et al 39 266 mg liposomal bupivacaine+75 mg bupivacaine hydrochloride150 mg bupivacaine hydrochloridePAISpinal or general anesthesiaTKANo financial funding
Schumer et al 40 266 mg liposomal bupivacaine+75 mg bupivacaine hydrochlorideBupivacaine hydrochloride (dose not stated)Local wound infiltrationSpinal anesthesiaTKANo financial funding
Vandepitte et al 41 133 mg liposomal bupivacaine+12.5 mg bupivacaine hydrochloride37.5 mg bupivacaine hydrochlorideInterscalene plexus blockGeneral anesthesiaMajor shoulder surgeryFunding by Pacira Pharmaceuticals
Wong et al 42 266 mg liposomal bupivacaine+75 mg bupivacaine hydrochloride125 mg bupivacaine hydrochlorideTAPGeneral anesthesiaLaparoscopic Roux-en-Y gastric bypass, sleeve gatsrectomy, sleeve to bypass conversionNo financial funding
Zlotnicki et al 43 266 mg liposomal bupivacaine100 mg bupivacaine hydrochloridePAISpinal anesthesiaTKANo financial funding

  • *With epinephrine.

  • PAI, periarticular injection; TAP, transversus abdominis plane block; TKA, total knee replacement.