Event severity scale | ||||||
Low | Moderate | Severe | Death | |||
Drug name | Drug class | Events (n) | Incident(s) | |||
Vincristine†‡ | Chemotherapy | 19 | 4 | 15 | ||
Potassium chloride† | N/A | 6 | 5 | 1 | ||
Bupivacaine§ | Local anesthetic | 5 | 1 | 4 | ||
Thiocolchicoside† | Muscle relaxant | 4 | 4 | |||
Gadolinium¶ | Contrast agent | 3 | 1 | 2 | ||
Ropivacaine§ | Local anesthetic | 3 | 1 | 2 | ||
Vecuronium† | Muscle relaxant | 3 | 1 | 2 | ||
Paracetamol† | Pain reliever | 2 | 1 | 1 | ||
Tranexamic acid‡ | Antifibrinolytic | 2 | 1 | 1 | ||
Oxytocin† | N/A | 2 | 2 | |||
Ephedrine† | Nonselective adrenergic agonist | 2 | 2 | |||
Succinylcholine† | General anesthetic | 2 | 2 | |||
Thiopental† | General anesthetic | 2 | 2 |
*Incident severity, as defined by the National Reporting and Learning System,23 is as follows: (Low) An unexpected or unintended incident that required extra observation or minor treatment and caused minimal harm to ≥1 person; (Moderate) Any unexpected or unintended incident that resulted in further treatment, possible surgical intervention, canceling of treatment, or transfer to another area, and which caused short-term harm to ≥1 person; (Severe) Any unexpected or unintended incident that caused permanent or long-term harm to ≥1 person; (Death) Any unexpected or unintended event that caused the death of ≥1 person.
†Intravenous to epidural.
‡Intravenous to intrathecal.
§Epidural to intravenous.
¶Intravenous to intraventricular/extraventricular.
N/A, not applicable.