Table 2

Patients’ pharmacokinetic parameters

PatientCmax (mg/L)Tpeak
(min)
AUC0-3
(mg hour/L)
T½ α
(min)
T½ β
(hours)
Lidocaine dose (mg)Infusion time (s)
13.755.6117.57.9210.040
23.253.7619.73.9245.060
32.353.0734.4*262.545
41.951.8312.02.7227.550
51.852.4719.53.2210.055
62.654.2811.92.3245.050
72.453.146.91.3260.060
83.052.8814.43.7210.045
91.252.332.4210.044
103.853.228.14.5280.050
Mean2.5953.2616.03.5236.049.9
SD0.841.088.31.926.16.8
Min1.21.836.91.321040
Max3.85.6134.47.928060
  • *One-compartment model+offset (=0.55 mg/L).

  • †One-compartment model, without fast concentration decay.

  • Cmax, maximum concentration; T½, half-life; Tpeak, time to peak.