Regression results using peripheral nerve block (PNB) dose in bupivacaine equivalents (BE) mg kg−1 as the dependent variable
| Variable | Estimate | 95% CI (LL to UL) | Cohen’s ƒ | P value |
| (Intercept) | 2.19 | (2.14 to 2.24) | ||
| Weight (kg) | −0.06 | (−0.06 to 0.06) | 0.3 | <0.001 |
| Age (years) | 0.002 | (0.001 to 0.003) | 0.03 | 0.032 |
| Ropivacaine | −0.18 | (−0.19 to 0.14) | 0.15 | <0.001 |
| Institution | 0.45 | <0.001 | ||
| Block type | 0.27 | <0.001 | ||
| Institution B | −0.87 | (−0.92 to 0.81) | <0.001 | |
| Institution C | −0.39 | (−0.48 to 0.29) | <0.001 | |
| Institution D | −1.15 | (−1.22 to 1.09) | <0.001 | |
| Institution E | −0.79 | (−0.84 to 0.73) | <0.001 | |
| Institution F | −0.39 | (−0.48 to 0.29) | <0.001 | |
| Institution G | −0.38 | (−0.45 to 0.31) | <0.001 | |
| Institution H | −1.06 | (−1.17 to 0.94) | <0.001 | |
| Institution I | −0.5 | (−0.61 to 0.40) | <0.001 | |
| Institution J | −0.24 | (−0.31 to 0.18) | <0.001 | |
| Institution K | −0.94 | (−1.02 to 0.86) | <0.001 | |
| Institution L | −0.31 | (−0.38 to 0.24) | <0.001 | |
| Institution N | −0.65 | (−0.73 to 0.57) | <0.001 | |
| Institution O | −0.66 | (−0.72 to 0.61) | <0.001 | |
| Institution P | −0.79 | (−0.85 to 0.74) | <0.001 | |
| Institution Q | −0.82 | (−0.9 to 0.74) | <0.001 | |
| Institution R | −1.06 | (−1.11 to 0.99) | <0.001 | |
| Institution S | −0.88 | (−0.94 to 0.83) | <0.001 | |
| Institution T | −1.12 | (−1.17 to 1.07) | <0.001 | |
| Institution V | −0.95 | (−1.0 to 0.89) | <0.001 | |
| Institution W | −0.68 | (−0.74 to 0.63) | <0.001 | |
| Institution X | −0.78 | (−0.83 to 0.72) | <0.001 | |
| IL/IH | −0.31 | (−0.33 to 0.29) | <0.001 | |
| Interscalene | −0.001 | (−0.03 to 0.01) | 0.5 | |
| Penile | −0.16 | (−0.19 to 0.14) | <0.001 | |
| Popliteal | −0.001 | (−0.03 to 0.01) | 0.32 | |
| Rectus sheath | −0.13 | (−0.15 to 0.11) | <0.001 | |
| Saphenous | −0.38 | (−0.4 to 0.36) | <0.001 | |
| Sciatic | −0.02 | (−0.04 to 0.002) | 0.03 | |
| Supraclavicular | −0.08 | (−0.1 to 0.06) | <0.001 | |
| TAP | −0.21 | (−0.23 to 0.2) | <0.001 |
Residual SE: 0.42 on 34 480 degrees of freedom.
Multiple R-squared: 0.2816, F-statistic: 409.5 and 34 480 DF, p value: <0.0001.
The estimate is the coefficient in the model. BE in mg kg−1 can be estimated as 2.18+(−0.006×weight)+(0.002×age)+(−0.18×LA dose if ropivacaine) plus the coefficients for institution and block type. Institution and block type are summarized in the Analysis of Variance (ANOVA) model.
LL and UL indicate the lower and upper limits of a 95% CI, respectively. Cohen’s ƒ estimate based on one-way ANOVA using the a priori chosen variables age, weight, local anesthetic, block type and institution. Cohen’s ƒ effect sizes of 0.1, 0.25 and 0.4 correspond to explained variance of 1%, 6% and 14%.
IL/IH, ilioinguinal/iliohypogastric; LA, local anesthetic; TAP, transverse abdominis plane.