Reported side effects
| Side effect | Number of included studies | Cannabinoid n/N | Control n/N | OR (99% CI) | P value for statistical significance | P value for heterogeneity | I2 test for heterogeneity |
| Randomized controlled trials | |||||||
| Allergic reaction | 1 | 0/52 | 1/53 | N/A | N/A | N/A | N/A |
| Anxiety | 1 | 2/40 | 0/16 | N/A | N/A | N/A | N/A |
| Apprehension | 1 | 1/40 | 0/16 | N/A | N/A | N/A | N/A |
| Blurred vision | 3 | 6/244 | 6/241 | 0.97 (0.31 to 3.04) | 0.95 | 0.70 | 0% |
| Change of mood | 3 | 9/232 | 6/204 | 1.51 (0.45 to 5.09) | 0.51 | 0.90 | 0% |
| Conjunctival injection | 2 | 1/92 | 1/69 | N/A | N/A | N/A | N/A |
| Delirium | 1 | 1/52 | 1/53 | N/A | N/A | N/A | N/A |
| Diarrhea | 1 | 3/61 | 1/62 | N/A | N/A | N/A | N/A |
| Difficulty with memory | 2 | 3/60 | 3/36 | N/A | N/A | N/A | N/A |
| Difficulty with sleep | 1 | 1/37 | 1/35 | N/A | N/A | N/A | N/A |
| Diplopia | 1 | 1/37 | 1/35 | N/A | N/A | N/A | N/A |
| Dizziness | 5 | 64/354 | 38/356 | 1.63 (0.33 to 8.15) | 0.55 | 0.0001 | 83% |
| Drowsiness | 4 | 71/284 | 63/257 | 1.61 (0.40 to 6.48) | 0.50 | 0.02 | 68% |
| Dry mouth | 3 | 49/232 | 49/204 | 0.87 (0.52 to 1.44) | 0.58 | 0.38 | 0% |
| Dyskinesia | 1 | 1/61 | 3/62 | N/A | N/A | N/A | N/A |
| Dysmenorrhea | 1 | 2/61 | 2/62 | N/A | N/A | N/A | N/A |
| Dysphoria | 1 | 2/40 | 0/16 | N/A | N/A | N/A | N/A |
| Euphoria | 1 | 0/172 | 0/168 | N/A | N/A | N/A | N/A |
| Hallucinations | 4 | 4/284 | 2/257 | 1.06 (0.19 to 5.99) | 0.95 | 0.60 | 0% |
| Headaches | 4 | 33/294 | 40/266 | 0.73 (0.42 to 1.26) | 0.25 | 0.88 | 0% |
| Hypotension | 4 | 28/322 | 12/346 | 3.24 (1.12 to 9.36) | 0.03 | 0.18 | 41% |
| Increased awareness of surroundings | 2 | 9/192 | 2/188 | N/A | N/A | N/A | N/A |
| Involuntary muscle twitching | 1 | 3/20 | 3/20 | N/A | N/A | N/A | N/A |
| Lack of concentration | 1 | 1/40 | 0/16 | N/A | N/A | N/A | N/A |
| Lack of energy | 1 | 8/172 | 8/168 | N/A | N/A | N/A | N/A |
| Lack of muscle coordination | 1 | 3/172 | 0/168 | N/A | N/A | N/A | N/A |
| Loud noise | 1 | 2/40 | 0/16 | N/A | N/A | N/A | N/A |
| Nausea | 6 | 47/271 | 49/277 | 1.03 (0.51 to 2.04) | 0.94 | 0.08 | 49% |
| Nervousness | 1 | 2/40 | 0/16 | N/A | N/A | N/A | N/A |
| Odynophagia | 1 | 2/61 | 3/62 | N/A | N/A | N/A | N/A |
| Palpitations | 1 | 8/20 | 5/20 | N/A | N/A | N/A | N/A |
| Pharyngolaryngeal pain | 1 | 3/61 | 4/62 | N/A | N/A | N/A | N/A |
| Poor appetite | 1 | 4/172 | 2/168 | N/A | N/A | N/A | N/A |
| Presyncope/syncope | 2 | 6/122 | 2/121 | N/A | N/A | N/A | N/A |
| Psychotic episodes | 1 | 0/20 | 0/21 | N/A | N/A | N/A | N/A |
| Fever | 1 | 5/61 | 4/62 | N/A | N/A | N/A | N/A |
| Respiratory insufficiency | 1 | 2/52 | 2/53 | N/A | N/A | N/A | N/A |
| Sensation disturbance | 1 | 2/172 | 1/168 | N/A | N/A | N/A | N/A |
| Slurring of speech | 2 | 4/72 | 3.73 | N/A | N/A | N/A | N/A |
| Tachycardia | 1 | 3/52 | 1/53 | N/A | N/A | N/A | N/A |
| Tremor | 1 | 1/20 | 2/20 | N/A | N/A | N/A | N/A |
| Uncooperative | 1 | 1/40 | 0/16 | N/A | N/A | N/A | N/A |
| Vomiting | 1 | 3/61 | 5/62 | N/A | N/A | N/A | N/A |
| Weakness | 1 | 1/40 | 1/16 | N/A | N/A | N/A | N/A |
| Weird dreams | 1 | 3/40 | 0/16 | N/A | N/A | N/A | N/A |
| Observational studies | |||||||
| Nausea | 2 | 22/146 | 36/162 | N/A | N/A | N/A | N/A |
| Acutely paranoid | 1 | 2/65 | N/A | N/A | N/A | N/A | N/A |
| Cognitive function | 1 | 1/64 | N/A | N/A | N/A | N/A | N/A |
| Dizziness | 1 | 4/64 | N/A | N/A | N/A | N/A | N/A |
| Unpleasant mood | 1 | 4/65 | N/A | N/A | N/A | N/A | N/A |
| Sensory disturbance | 1 | 1/65 | N/A | N/A | N/A | N/A | N/A |
| Sleep disturbance | 2 | 113/221 | 2058/3637 | N/A | N/A | N/A | N/A |
| Headache | 1 | 1/65 | N/A | N/A | N/A | N/A | N/A |
| Hypotension | 1 | 1/65 | N/A | N/A | N/A | N/A | N/A |
| Hypoxia | 1 | 1/65 | N/A | N/A | N/A | N/A | N/A |
| Cholinergic | 1 | 1/65 | N/A | N/A | N/A | N/A | N/A |
| Pulmonary embolism | 1 | 1/65 | N/A | N/A | N/A | N/A | N/A |
| Tachycardia | 1 | 1/65 | N/A | N/A | N/A | N/A | N/A |
| Dry mouth | 1 | 2/65 | N/A | N/A | N/A | N/A | N/A |
| Pallor | 1 | 2/65 | N/A | N/A | N/A | N/A | N/A |
| Fever | 1 | 1/65 | N/A | N/A | N/A | N/A | N/A |
*Data only pooled for those side effects with >2 studies.
n, number of patients.