Table 1

Differences in self-reported side effects from pain medication by lifetime abuse history

Side effectTotalNo abuseChild abuse onlyAdult abuse onlyCumulative abuseP value
(n=3118)(n=2639)(n=320)(n=86)(n=73)
% (n)% (n)% (n)% (n)% (n)
Any side effect69.18 (2157) 67.56 (1783) 78.13 (250) 72.09 (62) 84.93 (62) < 0.001
Drowsiness37.81 (1179) 36.42 (961) 42.19 (135) 47.67 (41) 57.53 (42) < 0.001
Constipation33.26 (1037) 31.68 (836) 39.69 (127) 41.86 (36) 52.05 (38) < 0.001
Fatigue28.90 (901) 27.40 (723) 33.75 (108) 32.56 (28) 57.53 (42) < 0.001
Dizziness22.71 (708)21.94 (579)25.00 (80)24.42 (21)38.36 (28)0.007
Nausea or vomiting15.11 (471) 13.98 (369) 20.00 (64) 20.93 (18) 27.40 (20) < 0.001
Confusion13.34 (416) 12.47 (329) 15.31 (49) 12.79 (11) 36.99 (27) < 0.001
Itchiness12.99 (405) 12.09 (319) 17.50 (56) 15.12 (13) 23.29 (17) 0.002
Other stomach/bowel upset11.26 (351) 10.19 (269) 17.19 (55) 12.79 (11) 21.92 (16) < 0.001
Mental impairment8.50 (265) 7.77 (205) 10.94 (35) 10.47 (9) 21.92 (16) < 0.001
Diarrhea7.02 (219) 6.14 (162) 10.00 (32) 11.63 (10) 20.55 (15) < 0.001
Swelling hands and/or feet6.77 (211)6.40 (169)7.81 (25)6.98 (6)15.07 (11)0.028
Difficulty urinating5.90 (184)5.49 (145)7.50 (24)6.98 (6)12.33 (9)0.049
Heart palpitations5.26 (164) 4.70 (124) 6.25 (20) 6.98 (6) 19.18 (14) < 0.001
Shortness of breath5.04 (157)4.66 (123)6.56 (21)6.98 (6)9.59 (7)0.103
Hallucinations2.89 (90)2.65 (70)4.69 (15)1.16 (1)5.48 (4)0.076
  • Bold faced results are significant at Bonferonni-corrected p<0.003.