RT Journal Article
SR Electronic
T1 Comparison of Bupivacaine and Lidocaine: General Anesthetic Potency and Therapeutic Index
JF Regional Anesthesia: The Journal of Neural Blockade in Obstetrics, Surgery, & Pain Control
JO Reg Anesth Pain Med
FD BMJ Publishing Group Ltd
SP 95
OP 98
DO 10.1136/rapm-00002370-198107000-00002
VO 6
IS 3
A1 James R. Niederlehner
A1 Cosmo A. DiFazio
YR 1981
UL http://rapm.bmj.com/content/6/3/95.abstract
AB From studies in rats, the plasma concentration and percent reduction of minimum anesthetic requirement (MAC) produced by bupivacaine were determined. In addition, mean convulsant blood levels of bupivacaine and lidocaine for the rat were determined. It was concluded that bupivacaine, a local anesthetic relatively devoid of the systemic effect of sedation, shows minimal general anesthetic potency as compared to lidocaine, despite its greater toxicity and potency as a local anesthetic.