RT Journal Article
SR Electronic
T1 Plasma Bupivacaine Concentrations Following Epidural Administration in Kidney Transplant Recipients
JF Regional Anesthesia: The Journal of Neural Blockade in Obstetrics, Surgery, & Pain Control
JO Reg Anesth Pain Med
FD BMJ Publishing Group Ltd
SP 308
OP 311
DO 10.1136/rapm-00115550-199621040-00007
VO 21
IS 4
A1 Golinar E. Hammouda
A1 Raida Yahya
A1 Mohamed M. Atallah
YR 1996
UL http://rapm.bmj.com/content/21/4/308.abstract
AB Background and Objective The typical hemodynamic and biochemical characteristics of kidney transplant recipients may influence the pharmacokinetic profile of bupivacaine following its epidural administration. The objective of this study was to test this hypothesis in kidney transplant recipients compared with kidney surgery patients.Methods In a prospective open comparative study, 10 kidney transplant recipients and 10 kidney surgery patients received bupivacaine by the lumbar epidural route during the course of their operations. Arterial blood sampling was carried out before administration of bupivacaine and at 2, 5, 10, 15, 20, 25, 30 minutes and subsequently at 1, 1.5, 2, 4, 8, and 24 hours, after its administration.Results The calculated pharmacokinetic variables did not show any significant difference between the two groups.Conclusions Lumbar epidural administration of bupivacaine is not associated with higher plasma bupivacaine concentrations in kidney transplant recipients than in nonuremic patients undergoing kidney surgery.