TY - JOUR T1 - Dose-Finding Methodology for Peripheral Nerve Blocks JF - Regional Anesthesia & Pain Medicine JO - Reg Anesth Pain Med SP - 550 LP - 555 DO - 10.1097/AAP.0000000000000157 VL - 39 IS - 6 AU - Theodosios Saranteas AU - Roderick J. Finlayson AU - De Q. H. Tran Y1 - 2014/11/01 UR - http://rapm.bmj.com/content/39/6/550.abstract N2 - Abstract Dose-finding studies enable the successful conduct of peripheral nerve blocks by ensuring the administration of appropriate doses of local anesthetic. However, the optimal dose-finding methodology remains ambiguous. In this research methodology article, we set out to review the basic aspects pertaining to dose-response curves (graded vs quantal), the pharmacodynamic indices required by dose-finding studies, the properties of different dose-finding methods (sigmoidal dose-response curve analysis, Dixon-Mood method, Biased Coin Design, and Bayesian analysis), as well as strategies and recommendations for future research. ER -