PT  - JOURNAL ARTICLE
AU  - Gul, Yagmur
AU  - Tutuncu, Ayse
AU  - Kendigelen, Pinar
TI  - OP035 Efficacy of dexmedetomidine as an adjuvant to Quadratus lumborum block for children undergoing inguinal surgeries. A prospective randomized trial
AID  - 10.1136/rapm-2023-ESRA.35
DP  - 2023 Sep 01
TA  - Regional Anesthesia & Pain Medicine
PG  - A20--A21
VI  - 48
IP  - Suppl 1
4099  - http://rapm.bmj.com/content/48/Suppl_1/A20.2.short
4100  - http://rapm.bmj.com/content/48/Suppl_1/A20.2.full
SO  - Reg Anesth Pain Med2023 Sep 01; 48
AB  - Please confirm that an ethics committee approval has been applied for or granted: Yes: I’m uploading the Ethics Committee Approval as a PDF file with this abstract submission Application for ESRA Abstract Prizes: I don’t wish to apply for the ESRA PrizesBackground and Aims We aimed to compare the effects and potential side effects of two different doses of dexmedetomidine, added as an adjuvant to bupivacaine in the QLB, on the time to first rescue analgesia requirement within the first 24hours postoperatively, postoperative pain scores, analgesic consumption, hemodynamic parameters, postoperative sedation, and agitation scores in pediatric patients undergoing inguinal region surgery.Methods A prospective, double-blind, randomized controlled study was conducted, including 60 patients aged between 1 and 7years undergoing inguinal region surgery. The QLB was performed in GroupI with bupivacaine only(0.25%,0.5ml/kg), in Group II added 0.5 μg/kg, and in GroupIII added 1μg/kg dexmedetomidine. Perioperative hemodynamic parameters, postoperative Ramsey Sedation and Watcha Behavior Scale, FLACC score within the first 24 hours, time to first analgesic requirement, and the amount of additional analgesic given were recorded.Results The time to request the first rescue analgesia was significantly prolonged in groupII and III[Mean±SD(95% CI)] 1128± 98.6(921.5-1334) and 1200±81.2(1030-1370) min. vs groupI 758±99.6(499.5-916.5) min.,p 0.001). We did not find a significant difference in the time to first rescue analgesia between Groups II and III. There was a significant decrease in the amount of rescue analgesia consumption in GroupII and III than Group I(p=0.001). We found higher Ramsey Sedation Scale scores and lower Watcha Behavior Scale scores in GroupsII and III.Conclusions Both doses of dexmedetomidine similarly have been shown to prolong the duration of analgesia, reduce postoperative pain scores and decrease the need for rescue analgesics. Therefore, the 0.5 μg/kg dose may be a good alternative to higher doses of dexmedetomidine.