PT - JOURNAL ARTICLE AU - Ferdinando, Longo AU - Caris, Francesca De AU - Strumia, Alessandro AU - Palminteri, Monica AU - Ricciardi, Renato AU - Agrò, Felice Eugenio TI - #36481 Combined us-guided erector spinae plane block (ESP) + parasternal block (PSB): new perspectives in opioid-free anesthesia for oncological major breast surgery AID - 10.1136/rapm-2023-ESRA.570 DP - 2023 Sep 01 TA - Regional Anesthesia & Pain Medicine PG - A298--A299 VI - 48 IP - Suppl 1 4099 - http://rapm.bmj.com/content/48/Suppl_1/A298.2.short 4100 - http://rapm.bmj.com/content/48/Suppl_1/A298.2.full SO - Reg Anesth Pain Med2023 Sep 01; 48 AB - Please confirm that an ethics committee approval has been applied for or granted: Not relevant (see information at the bottom of this page) Application for ESRA Abstract Prizes: I don’t wish to apply for the ESRA PrizesBackground and Aims In breast surgery, locoregional anesthesia has shown its effectiveness in pain management and in preventing the onset of post-mastectomy pain syndrome (PMPS). In particular, a totally opioid-free approach can be reserved for fragile patients. We experienced a series of ESP block and parasternal (PSB) block combination as a new approach for analgesia in modified radical mastectomy (MRM).Methods We selected five patients from 34 to 68 years old who underwent a modified radical mastectomy; ESP block was performed at T5 level with 25 ml of ropivacaine 0,5% and PSB block was administered with 10 ml of ropivacaine 0,5% between II and IV ribs for a better cover of the anteromedial wall chest. Patients underwent general anesthesia with a supraglottic device and opiods were given neither during or after surgery. Intravenous Paracetamol was provided every 8 hrs for 24 hrs.Results Pain score in a NRS scale, mgs of morphine demanded by patients and presence of PONV were recorded. Four of five patients reported a pain score<3 on the NRS scale, only 1 patient required 1 mg of morphine at 6 hrs with a score of 5 on NRS scale. No other symptoms were described. Furthermore, at a three-month post-operative follow-up, no pain >2 on the NRS scale was reported.Abstract #36481 Figure 1 US-guided ESP block usually performed in prone position at T5 level right before general anesthesiaAbstract #36481 Figure 2 US-guided PSB performed between the pectoral major muscle and the internal intercostal muscle right after putting the patient under general anesthesiaConclusions Combination of ESP block + PSB block has shown efficacy in ensuring good pain management during and after MRM in a totally opioid-free anesthesia perspective. Moreover, the low onset of pain at three months suggests its potential in PMPS prevention.