RT Journal Article
SR Electronic
T1 Adverse Drug Effects and Preoperative Medication Factors Related to Perioperative Low-Dose Ketamine Infusions
JF Regional Anesthesia & Pain Medicine
JO Reg Anesth Pain Med
FD BMJ Publishing Group Ltd
SP 482
OP 487
DO 10.1097/AAP.0000000000000416
VO 41
IS 4
A1 Eric S. Schwenk
A1 Stephen F. Goldberg
A1 Ronak D. Patel
A1 Jon Zhou
A1 Douglas R. Adams
A1 Jaime L. Baratta
A1 Eugene R. Viscusi
A1 Richard H. Epstein
YR 2016
UL http://rapm.bmj.com/content/41/4/482.abstract
AB Abstract High-dose opioid administration is associated with significant adverse events. Evidence suggests that low-dose ketamine infusions improve perioperative analgesia over conventional opioid management, but usage is highly variable. Ketamine's adverse drug effects (ADEs) are well known, but their prevalence during low-dose infusions in a clinical setting and how often they lead to infusion discontinuation are unknown. The purposes of this study were 3-fold: (1) to identify patient factors associated with initiation of ketamine infusions during spine surgery, (2) to identify specific spine procedures in which ketamine has been used most frequently, and (3) to identify ADEs associated with postoperative ketamine infusions and which ADEs most frequently led to discontinuation. Spine surgery was chosen because of its association with moderate to severe pain and a relatively high use of ketamine infusions in this population at our hospital.