RT Journal Article
SR Electronic
T1 No Tachyphylaxis During Postoperative Continuous Epidural 0.125% Bupivacaine Infusion
JF Regional Anesthesia: The Journal of Neural Blockade in Obstetrics, Surgery, & Pain Control
JO Reg Anesth Pain Med
FD BMJ Publishing Group Ltd
SP 117
OP 121
DO 10.1136/rapm-00115550-198813030-00005
VO 13
IS 3
A1 Mogensen, Torben
A1 Dirkes, William
A1 Bigler, Dennis
A1 Rosenberg, Jacob
A1 Ejdrup, Helle
A1 Kehlet, Henrik
YR 1988
UL http://rapm.bmj.com/content/13/3/117.abstract
AB The sensory level of analgesia and motor blockade were measured in 12 healthy patients undergoing gynecological laparotomy during combined epidural and general anesthesia. After the initial dose of 12 ml of plain bupivacaine 0.125%, a continuous epidural infusion of bupivacaine 0.125%, 12 ml/h, was initiated for pain treatment scheduled for 32 hours. No patients received narcotics. Initial level of sensory analgesia was Th6.8 ± 0.8 to S2.4 ± 1.1 (mean ± SEM). During the postoperative period six patients maintained the initial bilateral level of sensory analgesia and motor blockade. Five patients had a unilateral blockade. One patient had sufficient bilateral analgesia for 12 hours, but requested to withdraw from the study without giving a reason. Acute tolerance (tachyphylaxis) was not observed during the study, but half of the patients had a unilateral block.