PT  - JOURNAL ARTICLE
AU  - Mogensen, Torben
AU  - Dirkes, William
AU  - Bigler, Dennis
AU  - Rosenberg, Jacob
AU  - Ejdrup, Helle
AU  - Kehlet, Henrik
TI  - No Tachyphylaxis During Postoperative Continuous Epidural 0.125% Bupivacaine Infusion
AID  - 10.1136/rapm-00115550-198813030-00005
DP  - 1988 Jul 01
TA  - Regional Anesthesia: The Journal of Neural Blockade in Obstetrics, Surgery, & Pain Control
PG  - 117--121
VI  - 13
IP  - 3
4099  - http://rapm.bmj.com/content/13/3/117.short
4100  - http://rapm.bmj.com/content/13/3/117.full
SO  - Reg Anesth Pain Med1988 Jul 01; 13
AB  - The sensory level of analgesia and motor blockade were measured in 12 healthy patients undergoing gynecological laparotomy during combined epidural and general anesthesia. After the initial dose of 12 ml of plain bupivacaine 0.125%, a continuous epidural infusion of bupivacaine 0.125%, 12 ml/h, was initiated for pain treatment scheduled for 32 hours. No patients received narcotics. Initial level of sensory analgesia was Th6.8 ± 0.8 to S2.4 ± 1.1 (mean ± SEM). During the postoperative period six patients maintained the initial bilateral level of sensory analgesia and motor blockade. Five patients had a unilateral blockade. One patient had sufficient bilateral analgesia for 12 hours, but requested to withdraw from the study without giving a reason. Acute tolerance (tachyphylaxis) was not observed during the study, but half of the patients had a unilateral block.