RT Journal Article
SR Electronic
T1 Intravenous Regional Anesthesia for Operations in the Lower Limb: Effect of Two Different Concentrations of Chloroprocaine
JF Regional Anesthesia: The Journal of Neural Blockade in Obstetrics, Surgery, & Pain Control
JO Reg Anesth Pain Med
FD BMJ Publishing Group Ltd
SP 29
OP 32
DO 10.1136/rapm-00115550-198207010-00009
VO 7
IS 1
A1 Palas, T. A.R.
A1 Gerber, H. R.
YR 1982
UL http://rapm.bmj.com/content/7/1/29.abstract
AB The purpose of this investigation was to study the efficacy and safety of chloroprocaine at two different concentrations as a drug for intravenous regional anesthesia. Chloroprocaine was chosen as the local anesthetic because of its high rate of hydrolysis and low toxicity which permits the use of a large volume without a decrease in concentration. Two groups of patients undergoing elective surgery of the foot and ankle were studied. Group 1 (70 patients) received 60 mi of a 1% solution and Group 2 (140 patients), 60 ml of a 0.75% solution of chloroprocaine. All patients were premedicated with 10 mg diazepam, orally, one hour prior to surgery. Good surgical anesthesia was achieved in each case. The mean body weights and tourniquet times were comparable in both groups. Upon release of the tourniquet, there were fewer cardiovascular and/or cerebral reactions in Group 2 (9.3%) compared with Group 1 (22.9%). The need for analgesics in the first postoperative hour was 24.2% in Group 1, compared with 26.4% in Group 2. No signs of thrombophlebitis were seen in either group.